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S166

Sigma-Aldrich

Saclofen

solid

Synonym(s):

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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About This Item

Empirical Formula (Hill Notation):
C9H12ClNO3S
CAS Number:
125464-42-8
Molecular Weight:
249.71
MDL number:
MFCD00216817
UNSPSC Code:
51111800
PubChem Substance ID:
329824485
NACRES:
NA.32

form

solid

Quality Level

200

color

white

solubility

0.1 M NaOH: 20 mg/mL

SMILES string

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI key

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550) , GABBR2(9568)
mouse ... GABBR1(54393) , GABBR2(242425)
rat ... GABBR1(81657) , GABBR2(83633)

Application

Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.
Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.

Biochem/physiol Actions

Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.
Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in
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The Korean journal of pain, 32(3), 160-167 (2019-07-02)
Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and
N Bowery
Trends in pharmacological sciences, 10(10), 401-407 (1989-10-01)
Much progress has been made in GABAB receptor pharmacology since the discovery of this receptor in 1980. Selective agonists and antagonists have been developed and a functional role for the receptor as a mediator of slow inhibitory postsynaptic potentials in
Mahinda Kommalage et al.
European journal of pharmacology, 525(1-3), 69-73 (2005-11-22)
It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies
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