Skip to Content
Merck
All Photos(3)

Key Documents

View All Documentation

T33405

Sigma-Aldrich

Thiosemicarbazide

99%

Synonym(s):

TSC, TSZ, Thiocarbamoyl hydrazide

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Linear Formula:
NH2CSNHNH2
CAS Number:
79-19-6
Molecular Weight:
91.14
Beilstein:
506320
EC Number:
201-184-7
MDL number:
MFCD00007620
UNSPSC Code:
12352100
PubChem Substance ID:
24900132
NACRES:
NA.22

Quality Level

200

Assay

99%

mp

180-183 °C (dec.) (lit.)

SMILES string

NNC(N)=S

InChI

1S/CH5N3S/c2-1(5)4-3/h3H2,(H3,2,4,5)

InChI key

BRWIZMBXBAOCCF-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Thiosemicarbazide is generally condensed with aldehydes or ketones to synthesize wide range of thiosemicarbazones. It can be used to build a variety of heterocycles and bioactive molecules such as thiosemicarbazides, derivatives of thienopyrimidine urea and 2-amino thiadiazole.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300,H412

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 3

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.
Abdelhaleem EF, et al.
European Journal of Medicinal Chemistry, 143, 1807-1825 (2018)
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents.
Carradori S, et al.
European Journal of Medicinal Chemistry, 143, 1543-1552 (2018)
2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents.
Klayman DL, et al.
Journal of Medicinal Chemistry, 22(7), 855-862 (1979)
Thiosemicarbazides: synthesis and reactions.
Metwally MA, et al.
Journal of Sulfur Chemistry, 32(5), 489-519 (2011)
Exploiting the 2-Amino-1, 3, 4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
Linciano P, et al.
ACS Omega, 2(9), 5666-5683 (2017)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service