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C11006

Sigma-Aldrich

Carbohydrazide

98%

Synonym(s):

1,3-Diaminourea, Carbodihydrazide, Carbonohydrazide, N,N′-Diaminourea

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About This Item

Linear Formula:
CO(NHNH2)2
CAS Number:
497-18-7
Molecular Weight:
90.08
Beilstein:
1747069
EC Number:
207-837-2
MDL number:
MFCD00007591
UNSPSC Code:
12352100
PubChem Substance ID:
24892343
NACRES:
NA.22

Quality Level

200

Assay

98%

form

crystals

mp

150-153 °C (lit.)

SMILES string

NNC(=O)NN

InChI

1S/CH6N4O/c2-4-1(6)5-3/h2-3H2,(H2,4,5,6)

InChI key

XEVRDFDBXJMZFG-UHFFFAOYSA-N

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Application

Carbohydrazide can be used:
  • As an oxygen scavenger.
  • In the synthesis of polydentate Schiff base ligands with various aldehydes and ligands by condensation.
  • In the synthesis of trifluoromethyl-containing (E)-N′-arylidene-1H-pyrazole-1-carbohydrazides by cyclocondensation reaction which shows antioxidant and antimicrobial properties.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H315,H317,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Supplementary Hazards

EUH044

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL0948
STBK6570
STBJ7714
STBH8615
STBH4447

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Marta Kisiel et al.
Journal of controlled release : official journal of the Controlled Release Society, 162(3), 646-653 (2012-08-21)
Understanding the influence of formulation and storage conditions on rhBMP-2 bioactivity is extremely important for its clinical application. Reports in the literature show that different research groups employ different parameters such as formulation conditions, storage, doses for in vivo applications
Ameen Ali Abu-Hashem et al.
Acta pharmaceutica (Zagreb, Croatia), 60(3), 311-323 (2010-12-08)
2-Amino-5-acetyl-4-methyl-thiophene-3-carboxylic acid ethyl ester (1) and 5-acetyl-2-amino-4-methylthiophene-3-carbohydrazide (2) were synthesized and used as starting materials for the synthesis of new series of 1-(5-amino-4-(3,5-dimethyl-1H-pyrazole-1-carbonyl)-3-methylthiophen-2-yl) ethanone (3a), 1-(5-amino-4-(4-chloro-3,5-dimethyl-1H-pyrazole-1-carbonyl)-3-methylthiophen-2-yl) ethanone (3b), 1-(4-methyl-2-amino-5-acetylthiophene-3-carbonyl)pyrazolidine-3,5-dione (4), (Z)-N'-(4-methyl-2-amino-5-acetylthiophene-3-carbonyl) formohydrazonic acid (5a), (Z)-ethyl-N'-4-methyl-2-amino-5-acetylthiophene-3-carbonylformo hydrazonate (5b), 6-acetyl-3-amino-2,5-dimethylthieno[2,3-d]pyrimidin-4(3H)-one (8), 5-methyl-3-amino-2-mercapto-6-acetylthieno
Synthesis, structure and reactivity of zirconium (IV), vanadium (IV), cobalt (II), nickel (II) and copper (II) complexes derived from carbohydrazide schiff base ligands.
Warad, DU, et al.
Indian Journal of Chemistry, 39A(10), 415-420 (2000)
Mateusz Wierzbicki et al.
Nanoscale research letters, 14(1), 320-320 (2019-10-12)
Antibacterial surfaces coated with nanomaterials, including silver nanoparticles, are considered effective alternative antimicrobial agents that can be used instead of antibiotics and chemical agents. However, reports of the potential toxicity of these materials raise questions about the safety of their
Alessandro K Jordão et al.
Bioorganic & medicinal chemistry, 19(18), 5605-5611 (2011-08-16)
Tuberculosis treatment remains a challenge that requires new antitubercular agents due to the emergence of multidrug-resistant Mycobacterium strains. This paper describes the synthesis, the antitubercular activity and the theoretical analysis of N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (8a-b, 8e-f, 8i-j and 8n-o) and new analogues
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