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T0682

Sigma-Aldrich

Sodium taurohyodeoxycholate hydrate

≥98%

Synonym(s):

Taurohyodeoxycholic acid sodium salt hydrate

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About This Item

Linear Formula:
C26H44NO6SNa · xH2O
CAS Number:
38411-85-7
Molecular Weight:
521.69 (anhydrous basis)
MDL number:
MFCD09263185
UNSPSC Code:
12161900
PubChem Substance ID:
24899908
NACRES:
NA.25

description

anionic

Quality Level

100

Assay

≥98%

mol wt

521.69 g/mol (anhydrous basis)

application(s)

detection

SMILES string

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-;;/m1../s1

InChI key

MJKUJELEPWZEGU-IGEKTTBWSA-M

Related Categories

General description

Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent.

Application

Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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F Lanzarotto et al.
Scandinavian journal of gastroenterology, 36(9), 981-986 (2001-08-28)
Tauro-hyodeoxycholic acid is a hydrophilic bile acid of potential interest for treating cholestatic liver diseases. Bile acid pool is enriched with this bile acid during acute administration in patients with interrupted enterohepatic circulation. The aim of our study was to
F Feletti et al.
Arzneimittel-Forschung, 43(8), 888-893 (1993-08-01)
Fifty-two-week oral toxicity and 24-week intramuscular toxicity of a new synthetized biliary acid, taurohyodeoxycholic acid (Io, Praxis, CAS 2958-04-5) were investigated in dogs. Taurohyodeoxycholic acid was orally administered at dose levels up to 500 mg/kg/d and i.m. administered at dose
A S Tripodi et al.
Arzneimittel-Forschung, 43(8), 877-880 (1993-08-01)
In this study we investigated the anticholelithogenic and choleretic activities and the general pharmacological action of taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), a new biliary acid advocated for use as anticholelithogenic agent. THDCA had no significant activity on the
A S Tripodi et al.
Arzneimittel-Forschung, 43(8), 897-903 (1993-08-01)
The mutagenicity of a new biliary acid, taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), was assayed by using 5 different tests. The Ames test (reverse mutation assay on Salmonella typhimurium) and the DNA damage and repair test (in Saccharomyces cerevisiae)
A Roda et al.
Hepatology (Baltimore, Md.), 27(2), 520-525 (1998-02-14)
The prevention of the hepatotoxic effects produced by intravenous infusion of taurochenodeoxycholic acid (TCDCA) by coinfusion with taurohyodeoxycholic acid (THDCA) was evaluated in bile fistula rats; the hepatoprotective effects of the latter were also compared with those of tauroursodeoxycholic acid
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