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1441301

USP

Metoprolol tartrate

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

Lopressor

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About This Item

Formule linéaire :
(C15H25NO3)2 · C4H6O6
Numéro CAS:
56392-17-7
Poids moléculaire :
684.81
Numéro MDL:
MFCD00056257
Code UNSPSC :
41116107
ID de substance PubChem :
329750297
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

metoprolol

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2

InChI

1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1

Clé InChI

YGULWPYYGQCFMP-CEAXSRTFSA-N

Informations sur le gène

human ... ADRB1(153)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metoprolol tartrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Metoprolol Tartrate and Hydrochlorothiazide Tablets
  • Metoprolol Tartrate Compounded Oral Solution
  • Metoprolol Tartrate Compounded Oral Suspension
  • Metoprolol Tartrate Injection
  • Metoprolol Tartrate Tablets

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0000145

Metoprolol impurity A, European Pharmacopoeia (EP) Reference Standard

1441243

Metoprolol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1441254

Metoprolol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1441265

Metoprolol Related Compound D, United States Pharmacopeia (USP) Reference Standard

1441298

Metoprolol succinate, United States Pharmacopeia (USP) Reference Standard

1441232

Metoprolol Related Compound A, United States Pharmacopeia (USP) Reference Standard

1441287

Metoprolol fumarate, United States Pharmacopeia (USP) Reference Standard

BP540

Metoprolol tartrate, British Pharmacopoeia (BP) Reference Standard

PHR9038

Metoprolol EP Impurity B, reference material

PHR9039

Metoprolol EP Impurity G, reference material

PHR9068

Metoprolol EP Impurity H, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2509

Metoprolol Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR9101

Metoprolol EP Impurity E, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2510

Metoprolol Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2511

Metoprolol succinate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR3046

Metoprolol Fumarate, pharmaceutical secondary standard, certified reference material

Pictogrammes

Health hazardEnvironment
GHS08,GHS09

Mention d'avertissement

Warning

Mentions de danger

H361d,H411

Classification des risques

Aquatic Chronic 2 - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Design and evaluation of mucoadhesive buccal drug delivery systems containing metoprolol tartrate.
Ramana, M. V., C. Nagda, and M. Himaja.
Indian Journal of Pharmaceutical Sciences, 69.4, 515-515 (2007)
C Narendra et al.
AAPS PharmSciTech, 7(2), E34-E34 (2006-06-27)
The purpose of the present study was to develop an optimized gastric floating drug delivery system (GFDDS) containing metoprolol tartrate (MT) as a model drug by the optimization technique. A 2(3) factorial design was employed in formulating the GFDDS with
Wenhuan Li et al.
Medicine, 93(28), e329-e329 (2014-12-20)
The sensitivity and specificity of 5 different image sets of dual-energy computed tomography (DECT) for the detection of first-pass myocardial perfusion defects have not systematically been compared using positron emission tomography (PET) as a reference standard. Forty-nine consecutive patients, with
Reply: Carvedilol versus metoprolol, but which metoprolol? Effect on inappropriate cardioverter-defibrillator therapy.
Martin H Ruwald et al.
Journal of the American College of Cardiology, 63(18), 1933-1934 (2014-02-04)
I S Hamadeh et al.
Clinical pharmacology and therapeutics, 96(2), 175-181 (2014-03-19)
Metoprolol is a selective β-1 adrenergic receptor blocker that undergoes extensive metabolism by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). Our objective was to investigate the influence of CYP2D6 polymorphisms on the efficacy and tolerability of metoprolol tartrate. Two hundred
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