M5391

(±)-Metoprolol (+)-tartrate salt

≥98% (titration), powder

• Synonyme(s) : Lopressor
• Formule linéaire : (C₁₅H₂₅NO₃)₂ · C₄H₆O₆
• Numéro CAS: 56392-17-7
• Poids moléculaire : 684.81
• Numéro CE : 260-148-9
• Numéro MDL: MFCD00056257
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278556
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 200
• Pureté: ≥98% (titration)
• Forme: powder
• Couleur: white to off-white
• Solubilité: H₂O: 50 mg/mL
• Auteur: Novartis
• Chaîne SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.COCCc1ccc(OCC(O)CNC(C)C)cc1.COCCc2ccc(OCC(O)CNC(C)C)cc2
• InChI: 1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
• Clé InChI: YGULWPYYGQCFMP-CEAXSRTFSA-N
• Informations sur le gène: human ... ADRB1(153)

Description

Description générale

Metoprolol has antihypertensive and anti-ischemic properties. It is used to treat arrhythmias.

Application

(±)-Metoprolol (+)-tartrate salt has been used:

• to modulate the immunological parameters in various studies
• to study its effects onCa²⁺-calmodulin-dependent protein kinase II (CaMKII) activity in human and experimental heart failure (HF)
• to examine the contribution of the adrenergic receptors to the production of norepinephrine (NE)-mediated O^2-

Actions biochimiques/physiologiques

β₁-adrenoceptor antagonist.

Caractéristiques et avantages

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This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

Shelf-life of the powder is at least 4 years.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H361d,H411
• Conseils de prudence: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Classification des risques: Aquatic Chronic 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)