1327000

Hydroxychloroquine sulfate

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
• Formule empirique (notation de Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Numéro CAS: 747-36-4
• Poids moléculaire : 433.95
• Numéro CE : 212-019-3
• Numéro MDL: MFCD00078203
• Code UNSPSC : 41116107
• ID de substance PubChem : 329750122
• Nomenclature NACRES : NA.24

Propriétés

• Source biologique: synthetic
• Qualité: pharmaceutical primary standard
• Agence: USP
• Famille d'API: hydroxychloroquine
• Conditionnement: pkg of 200 mg
• Fabricant/nom de marque: USP
• Conditions de stockage: protect from light
• Couleur: white to off-white
• pH: 3.5-5.5 (1% in aqueous solution, pH <6.0)
• Pf: 388.4 °F (198°C; 240°C)
• Solubilité: chloroform: practically insoluble; ethanol: practically insoluble; ether: practically insoluble; water: soluble
• Application(s): pharmaceutical (small molecule)
• Format: neat
• Chaîne SMILES: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• Clé InChI: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Informations sur le gène: human ... TLR7(51284) , TLR9(54106)

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Hydroxychloroquine Sulfate is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.

Application

Hydroxychloroquine sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Hydroxychloroquine Sulfate Tablets
• Hydroxychloroquine Sulfate Compounded Oral Suspension
• Chloroquine Phosphate

Actions biochimiques/physiologiques

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319
• Conseils de prudence: P301 + P312 + P330 - P305 + P351 + P338
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable