Y0002361

Saxagliptin

for system suitability CRS, European Pharmacopoeia (EP) Reference Standard

• Synonyme(s) : Saxagliptin hydrate, (S)-3-Hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile hydrate, BMS 477118, BMS 477118-11, BMS-477118, BMS-477118-11, BMS477118, BMS477118-11
• Formule empirique (notation de Hill): C₁₈H₂₅N₃O₂ · H₂O
• Numéro CAS: 945667-22-1
• Poids moléculaire : 333.43
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: pharmaceutical primary standard
• Famille d'API: saxagliptin
• Fabricant/nom de marque: EDQM
• Application(s): pharmaceutical
• Température de stockage: 2-8°C
• Chaîne SMILES: OC12CC([C@@H](C(N3[C@@H](C[C@]4([C@@]3(C4)[H])[H])C#N)=O)N)(CC(C5)C2)CC5C1.O
• InChI: 1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10?,11?,12-,13+,14+,15-,17?,18?;/m1./s1
• Clé InChI: AFNTWHMDBNQQPX-NHKADLRUSA-N

Description

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Saxagliptin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

Conditionnement

Unit quantity: 1.082mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H317,H334,H361fd,H372
• Conseils de prudence: P202 - P260 - P264 - P280 - P302 + P352 - P308 + P313
• Classification des risques: Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT RE 1
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable