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T3396

Sigma-Aldrich

Tetraglycol

BioXtra

Synonyme(s) :

Glycofurol, Tetrahydrofurfuryl alcohol polyethyleneglycol ether

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About This Item

Numéro CAS:
31692-85-0
Numéro MDL:
MFCD00801146
Code UNSPSC :
12352201
Nomenclature NACRES :
NA.25

Description

non-ionic

Niveau de qualité

200

Gamme de produits

BioXtra

Forme

liquid (clear)

Impuretés

<0.5% water (Coulometric)
<5 ppm heavy metal

Couleur

colorless to light yellow

Pf

≤ -100  °C

Solubilité

water: soluble 3420 g/L

Densité

1.09 g/mL at 25 °C (lit.)

InChI

1S/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2

Clé InChI

CTPDSKVQLSDPLC-UHFFFAOYSA-N

Catégories apparentées

Application

Tetraglycol has been used:
  • to dilute DiI (1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate) for injecting fertilized chicken eggs for DiI labeling
  • to dilute DiI (1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perchlorate) and diO (3,3′-dioctadecyloxacarbocyanine perchlorate) for dye/virus injections
  • to dilute poly (lactide-co-glycolide) (PLGA) to prepare PLGA/F127 solution

Used as solvent to dissolve water-insoluble compounds.

Actions biochimiques/physiologiques

Liquid glycofurol can readily transform into gel systems with excellent elasticity due to which, it can be used as a medium to dissolve water-insoluble drugs.

Caractéristiques et avantages

Efficient solubilizer for glibenclamide (GBD)

Attention

Do not confuse with tetraethylene glycol, which is also sometimes called tetraglycol.

Autres remarques

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319

Classification des risques

Eye Irrit. 2

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

275.0 °F - closed cup

Point d'éclair (°C)

135 °C - closed cup

Équipement de protection individuelle

Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Saly Galal et al.
Acta pharmaceutica (Zagreb, Croatia), 53(1), 57-64 (2004-02-11)
The ability of liquid and semi-solid matrix (SSM) filling capsule technology to improve the dissolution rate of glibenclamide (GBD) was investigated. Semiquantitative estimation of GBD solubility in various vehicles was carried out. Tetraglycol was found to be the most efficient
X F Zhang et al.
Materials science & engineering. C, Materials for biological applications, 32(6), 1654-1663 (2012-08-01)
Poly (lactide-co-glycolide) (PLGA) - Pluronic F127 - glass composites have demonstrated excellent potential, from the perspective of controlled mechanical properties and cytocompatibility, for peripheral nerve regeneration. In addition to controlling the mechanical properties and cytotoxicity for such composite devices, the
Nahla Salah Barakat
AAPS PharmSciTech, 11(3), 1138-1146 (2010-07-24)
In view of the good skin tolerability, glycofurol was used as a vehicle-based gel, and its effect in the topical penetration of Naproxen (NAP) was investigated. The aims of this study were to develop a suitable gel with bioadhesive property
S Kehoe et al.
Journal of the mechanical behavior of biomedical materials, 14, 180-185 (2012-10-03)
PLGA/pluronic F127 based nerve guidance conduits (NGCs) for peripheral nerve regeneration offer excellent potential for clinical use. To date, little emphasis has been directed towards the effect of pluronic F127 on their subsequent mechanical properties as a function of degradation

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