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SRP5255

Sigma-Aldrich

HSP70, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

HSP70-1, HSP72, HSPA1, HSPA1A, HSPA1B. DAQB-147D11.1

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About This Item

Numéro CAS:
2071612-66-1
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in E. coli

Pureté

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Poids mol.

~96 kDa

Numéro d'accès NCBI

NM_005345

Application(s)

cell analysis

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... HSPA1A(3303)

Description générale

HSP70 is a member of the heat shock protein family and is synthesized by cells of many organisms in response to stress. HSP70 is found mostly but not exclusively in the nucleus of unstressed cells. For several hours after a short heat shock, however, it is strongly concentrated in nucleoli. Nucleoli are transiently damaged by such a heat shock: their morphology changes and assembly and export of ribosomes is blocked for several hours. HSP70 helps to stabilize the morphological changes of the nucleoli.
HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) is also termed as HSP72. It belongs to the molecular chaperones family. This gene is located on human chromosome 6p21.

Actions biochimiques/physiologiques

HSP70 (heat shock 70kDa)/Hsp70A1A (heat shock 70kDa protein 1A) participates in several cellular processes, such as thermotolerance, clearance of protein aggregate, survival and proliferation. Mutation in Hsp70 gene locus is linked with systemic lupus erythematosus. Overexpression of this protein is observed in valproic acid (VPA)-resistant cell lines.

Forme physique

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Notes préparatoires

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients
Pae C U, et al.
Neuropsychobiology, 59(3), 135-141 (2009)
Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus
Furnrohr BG, et al.
Annals of the Rheumatic Diseases, annrheumdis122630-annrheumdis122630 (2010)
HSP72 functionally inhibits the anti-neoplastic effects of HDAC inhibitors
Fujii K, et al.
Journal of Dermatological Science, 90(1), 82-89 (2018)
Engagement of Components of DNA-Break Repair Complex and NF kappaB in Hsp70A1A Transcription Upregulation by Heat Shock
Hazra J, et al.
Testing, 12(1), e0168165-e0168165 (2017)

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