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SML2486

Sigma-Aldrich

Peramivir trihydrate

≥98% (HPLC)

Synonyme(s) :

(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxycyclopentanecarboxylic acid trihydrate

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About This Item

Formule empirique (notation de Hill):
C15H28N4O4 · 3H2O
Numéro CAS:
1041434-82-5
Poids moléculaire :
382.45
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Activité optique

[α]/D -125 to -145°, c = 0.1 in H2O

Couleur

white to beige

Solubilité

DMSO: 2 mg/mL, clear

Température de stockage

2-8°C

InChI

1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19);3*1H2/t9-,10+,11+,12-,13+;;;/m0.../s1

Clé InChI

RFUCJKFZFXNIGB-ZBBHRWOZSA-N

Actions biochimiques/physiologiques

Peramivir exhibits antiviral activity against type A and B influenza virus including pandemic influenza A/H1N1 virus. It also exhibits its antiviral effects on avian influenza viruses like H5N1 and H9N2 strains.
Peramivir is an Influenza viral neuraminidase inhibitor.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Masanori Kobayashi et al.
Antiviral research, 139, 41-48 (2016-12-26)
High morbidity and mortality associated with human cases of highly pathogenic avian influenza (HPAI) viruses, including H5N1 influenza virus, have been reported. The purpose of the present study was to evaluate the antiviral effects of peramivir against HPAI viruses. In
Zhengtu Li et al.
BMC infectious diseases, 16, 325-325 (2016-07-10)
China-made Peramivir, an anti-influenza neuraminidase inhibitor drug, is manufactured and widely used in China. Although effective if initiated within 48 h of the onset of symptoms, yet we observed that this drug shows an inconclusive efficacy if treatment is delayed in
Makoto Kodama et al.
Antiviral research, 109, 110-115 (2014-07-06)
The purpose of this study was to investigate the relationship between pharmacokinetic (PK) parameters of intravenous (IV) peramivir and in vivo antiviral activity pharmacodynamic (PD) outcomes in a mouse model of influenza virus infection. Peramivir was administrated to mice in
Jung-Wan Yoo et al.
Journal of medical virology, 87(10), 1649-1655 (2015-05-07)
The clinical efficacy of peramivir in the treatment of severe seasonal influenza in critically ill patients admitted to an intensive care unit (ICU) is not well established. The aim of this study was to compare the clinical efficacy of peramivir

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