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Merck
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Key Documents

SML1496

Sigma-Aldrich

Buformin hydrochloride

≥98% (HPLC)

Synonyme(s) :

1-Butylbiguanide hydrochloride, N-Butyl-imidodicarbonimidic diamide hydrochloride

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About This Item

Formule empirique (notation de Hill):
C6H15N5 · HCl
Numéro CAS:
1190-53-0
Poids moléculaire :
193.68
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

H2O: 25 mg/mL, clear

Température de stockage

−20°C

InChI

1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H

Clé InChI

KKLWSPPIRBIEOV-UHFFFAOYSA-N

Application

Buformin hydrochloride has been used as an internal standard in liquid chromatography-tandem mass spectrometry to analyze postmortem distribution/redistribution of buformin in body fluids and solid tissues in an autopsy case.

Actions biochimiques/physiologiques

Buformin is an oral antidiabetic drug with antiproliferative properties; AMPK activator. Buformin, an antidiabetic biguanide drug, was withdrawn as an antidiabetic drug in several countries because of the side effect of lactic acidosis, but is now being investigated as an anticancer agent. Buformin inhibits the growth and development of cancer. Buformin has been shown to postpone spontaneous carcinogenesis as well as inhibit induced carcinogenesis in animal studies. Buformin decreased cancer incidence, multiplicity, and burden in a rat study of chemically induced mammary carcinogenesis. Buformin also reduced renal cell carcinoma survival under conditions of glucose deprivation. Buformin′s anticancer activity is thought to involve disruption of the Warburg effect by AMPK activation, which decreases hepatic glucose production, and inhibition of the mTor pathway.

Pictogrammes

CorrosionExclamation mark
GHS05,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H315,H318,H335

Classification des risques

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Amin Wurita et al.
Forensic science international, 314, 110376-110376 (2020-07-03)
An autopsy for a suicidal case of a male in his 40s, who had died of poisoning due to ingestion of a large amount of buformin, was performed at our department. Buformin is biganide class agent used for patients of
Yan Ding et al.
Open life sciences, 15(1), 409-417 (2021-04-06)
Buformin has been reported to be a powerful anticancer drug by activating the AMPK signal. Herein, we aimed to investigate the effects of buformin on osteosarcoma. Cellular proliferative abilities were determined by cell counting kit-8 and colony formation assays. Cellular

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