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SML1078

Sigma-Aldrich

4-Bromo-Resveratrol

≥98% (HPLC)

Synonyme(s) :

5-[(1E)-2-(4-Bromophenyl)ethenyl]-1,3-benzenediol

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About This Item

Formule empirique (notation de Hill):
C14H11BrO2
Numéro CAS:
1224713-90-9
Poids moléculaire :
291.14
Numéro MDL:
MFCD00238583
Code UNSPSC :
12352200
ID de substance PubChem :
329825458
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

protect from light

Couleur

, white to yellow to brown

Solubilité

DMSO: 20 mg/mL, clear

Température de stockage

2-8°C

Chaîne SMILES 

OC1=CC(/C=C/C2=CC=C(Br)C=C2)=CC(O)=C1

InChI

1S/C14H11BrO2/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,16-17H/b2-1+

Clé InChI

NCJVLKFAQIWASE-OWOJBTEDSA-N

Description générale

4-Bromo-Resveratrol blocks the activity of human sirtuin 1 (sirt1) and sirt3 by binding to C-site and another active site pocket.

Actions biochimiques/physiologiques

4-Bromo-Resveratrol is a resveratrol analog that potently inhibits Sirt1 and Sirt3.

Caractéristiques et avantages

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Autres remarques

light sensitive

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Viniferin ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00074

Viniferin

Resveratrol A phenolic product found in both grape skins and wines.

Sigma-Aldrich

554325

Resveratrol

Pterostilbene ≥97% (HPLC), solid

Sigma-Aldrich

P1499

Pterostilbene

Polydatin ≥95% (HPLC)

Sigma-Aldrich

15721

Polydatin

Resvératrol United States Pharmacopeia (USP) Reference Standard

USP

1602105

Resvératrol

Nicotinamide ≥98% (HPLC), powder

Sigma-Aldrich

N3376

Nicotinamide

JC-1 powder or solid (Crystals)

Sigma-Aldrich

T4069

JC-1

Dansylcadaverine ≥97% (TLC)

Sigma-Aldrich

D4008

Dansylcadaverine

Resvératrol analytical standard

Supelco

34092

Resvératrol

trans-Stilbene 96%

Sigma-Aldrich

139939

trans-Stilbene

Giang Thi Tuyet Nguyen et al.
Chemistry & biology, 20(11), 1375-1385 (2013-11-12)
Sirtuins are protein deacetylases regulating aging processes and various physiological functions. Resveratrol, a polyphenol found in red wine, activates human Sirt1 and inhibits Sirt3, and it can mimic calorie restriction effects, such as lifespan extension in lower organisms. The mechanism
Mengling Li et al.
Redox biology, 36, 101632-101632 (2020-08-31)
Recent research suggests that melatonin (Mel), an endogenous hormone and natural supplement, possesses anti-proliferative effects and can sensitise cells to anti-cancer therapies. Although shikonin (SHK) also possesses potential anti-cancer properties, the poor solubility and severe systemic toxicity of this compound
Liang-Jun Wang et al.
Biochemical pharmacology, 162, 154-168 (2018-11-11)
Albendazole (ABZ) is a microtubule-targeting anthelmintic that acts against a variety of human cancer cells, but the dependence of its cytotoxicity on non-mitotic effect remains elusive. Thus, we aimed to explore the mechanistic pathway underlying the cytotoxicity of ABZ in

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