SML0603

Lixivaptan

≥96% (HPLC)

• Synonyme(s) : N-[3-Chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methylbenzamide, VPA 985, WAY-VPA 985
• Formule empirique (notation de Hill): C₂₇H₂₁ClFN₃O₂
• Numéro CAS: 168079-32-1
• Poids moléculaire : 473.93
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Description: 4% w/w in ethyl acetate
• Niveau de qualité: 100
• Pureté: ≥96% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 20 mg/mL, clear
• Température de stockage: room temp
• InChI: 1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
• Clé InChI: PPHTXRNHTVLQED-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Arginine vasopressin (AVP) plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). Lixivaptan is an AVP V2-receptor selective antagonist that increases water excretion and normalizes serum sodium levels. Lixivaptan has been in clinical trials for hyponatremia associated with heart failure.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable