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Key Documents

SML0711

Sigma-Aldrich

RS504393

≥98% (HPLC)

Synonyme(s) :

6-Methyl-1′-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4′-piperidin]-2(1H)-one, RS-504393

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About This Item

Formule empirique (notation de Hill):
C25H27N3O3
Numéro CAS:
300816-15-3
Poids moléculaire :
417.50
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: 1 mg/mL, clear (warmed)

Température de stockage

2-8°C

InChI

1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

Clé InChI

ODNICNWASXKNNQ-UHFFFAOYSA-N

Application

RS504393 has been used in mass spectrometry.

Actions biochimiques/physiologiques

RS504393 helps to increase the analgesic potency of morphine and buprenorphine in neuropathic rats. RS504393 has the ability to block the upregulation of pronociceptive factors, like IL-1 (interlukin 1) β, IL-18 (interlukin 18), IL-6 (interlukin 6) and inducible nitric oxide synthase (iNOS), that are induced by chronic constriction injury (CCI).
RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys.

Caractéristiques et avantages

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats
Kwiatkowski K, et al.
Journal of Neuroimmune Pharmacology, 12(3), 402-419 (2017)
Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis
Winter C, et al.
Cell Metabolism (2018)
Bradley W Richmond et al.
Mucosal immunology, 14(2), 431-442 (2020-09-25)
Although activation of adaptive immunity is a common pathological feature of chronic obstructive pulmonary disease (COPD), particularly during later stages of the disease, the underlying mechanisms are poorly understood. In small airways of COPD patients, we found that localized disruption
Maira Licia Foresti et al.
Epilepsy & behavior : E&B, 102, 106695-106695 (2019-12-01)
Neuroinflammation role on epileptogenesis has been the subject of increasing interest. Many studies showed elevation in cytokines and chemokines expression following seizures, such as, CCL2 protein (C-C motif ligand 2 chemokine) and its specific receptor, CCR2. In addition, recent studies

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Chemokine Receptors

We offer many products related to chemokine receptors for your research needs.

Chemokine Receptors

We offer many products related to chemokine receptors for your research needs.

Chemokine Receptors

We offer many products related to chemokine receptors for your research needs.

Chemokine Receptors

We offer many products related to chemokine receptors for your research needs.

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