SML0187

CJ-13610

≥98% (HPLC)

• Synonyme(s) : Tetrahydro-4-[3-[[4-(2-methyl-1H-imidazol-1-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
• Formule empirique (notation de Hill): C₂₂H₂₃N₃O₂S
• Numéro CAS: 179420-17-8
• Poids moléculaire : 393.50
• Numéro MDL: MFCD00948114
• Code UNSPSC : 51111800
• ID de substance PubChem : 329825216
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: DMSO: ≥10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1nccn1-c2ccc(Sc3cccc(c3)C4(CCOCC4)C(N)=O)cc2
• InChI: 1S/C22H23N3O2S/c1-16-24-11-12-25(16)18-5-7-19(8-6-18)28-20-4-2-3-17(15-20)22(21(23)26)9-13-27-14-10-22/h2-8,11-12,15H,9-10,13-14H2,1H3,(H2,23,26)
• Clé InChI: VPTONMHDLLMOOV-UHFFFAOYSA-N

Description

Application

CJ-13610 may be used to study 5-lipoxygenase-mediated cell signaling.

Actions biochimiques/physiologiques

CJ-13,610 is a potent inhbititor of 5-lipoxygenase (5-LO) activity (IC₅₀ = 70 nM).

CJ-13610 inhibits the biosynthesis of leukotriene B4 and regulates the IL-6 mRNA expression in macrophages. It reduces fibrosis and necroinflammation of liver in carbon tetrachloride-treated mice.

Caractéristiques et avantages

This compound is featured on the Leukotriene Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable