SMB00579

Tacalcitol

≥99% (HPLC)

• Synonyme(s) : (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D₃
• Formule empirique (notation de Hill): C₂₇H₄₄O₃
• Numéro CAS: 57333-96-7
• Poids moléculaire : 416.64
• Numéro MDL: MFCD00866623
• Code UNSPSC : 12352205
• ID de substance PubChem : 329825068
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥99% (HPLC)
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: white to off-white
• Température de stockage: −20°C
• Chaîne SMILES: C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C
• InChI: 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
• Clé InChI: BJYLYJCXYAMOFT-RSFVBTMBSA-N

Description

Description générale

Tacalcitol is a synthetic vitamin D₃ analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.

Actions biochimiques/physiologiques

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P301 + P330 + P331 + P310
• Classification des risques: Acute Tox. 1 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable