SAB4700094

Monoclonal Anti-CD9-Biotin antibody produced in mouse

clone MEM-61, purified immunoglobulin, buffered aqueous solution

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: biotin conjugate
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: MEM-61, monoclonal
• Forme: buffered aqueous solution
• Espèces réactives: human
• Concentration: 1 mg/mL
• Technique(s): flow cytometry: suitable
• Isotype: IgG1
• Numéro d'accès NCBI: NM_001769.3
• Numéro d'accès UniProt: P21926
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CD9(928)

Description

Description générale

Cluster of differentiation 9 (CD 9) molecule, a member of transmembrane 4 super family (TM4SF) or tetraspanin superfamily, possesses four transmembrane domain. In human chromosome, the gene CD9 is localized on 12p13.31. The antibody MEM-61 recognizes an epitope on second extracellular domain (EC2) of CD9 antigen, a 24 kDa transmembrane protein expressed on platelets, monocytes, pre-B lymphocytes, granulocytes and activated T lymphocytes.

Immunogène

Pre-B cell line NALM-6

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1:400. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Actions biochimiques/physiologiques

Functions of cluster of differentiation 9 (CD9) molecule (CD9) include cell proliferation, activation, motility, and metastasis of tumor cells. CD9 along with CD81 is implicated to play a key role in muscle cell fusion and myotube maintenance. CD9 is associated with Interleukin 16 (IL-16) and induces migration and activation of mast cells. CD9 is involved in megakaryopoiesis. CD9 is expressed in Cord Blood CD34+ cells and might play a key role in hematopoietic stem cell (HSC) homing. CD9 associates with β1 integrin, membrane type 1−matrix metalloproteinase (MT1-MMP) and CD26 for HSC motility and homing. CD9 is crucial for sperm-egg fusion during fertilization. CD9 is a key molecule for glycoprotein 130 (gp130) mediated tumorigenic signal transduction in glioblastoma and a potential target for therapy.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable