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Key Documents

SAB4502676

Sigma-Aldrich

Anti-S6 Ribosomal Protein, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

40S ribosomal protein S6, Phosphoprotein NP33, RPS6, RS6, ribosomal protein S6

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 28 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... RPS6(6194)

Description générale

Anti-S6 Ribosomal protein antibody detects endogenous levels of total S6 Ribosomal protein protein.
The RPS6 (ribosomal protein S6) gene is mapped to human chromosome 9p22.1.

Immunogène

The antiserum was produced against synthesized peptide derived from human S6 Ribosomal Protein.

Immunogen Range: 191-240

Actions biochimiques/physiologiques

The RPS6 (ribosomal protein S6) protein is involved in the 40S subunit assembling. RpS6 might be involved in the regulation of cellular metabolism, the size of cells, their proliferation and survival. RpS6 might stimulate or inhibit translation of certain mRNA. Upregulation of the gene is observed in pulmonary sclerosing hemangioma, lymphangioleiomyomatosis-associated angiomyolipomas, dysplasia, oral cavity and esophageal squamous cell carcinoma.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer.
Chen B
Journal of Experimental & Clinical Cancer Research, 34:126, 1-16 (2015)
Janice Chithelen et al.
Frontiers in physiology, 13, 856143-856143 (2022-04-05)
The bioactive sphingolipids ceramide and sphingosine-1-phosphate (S1P) are involved in the regulation of cell homeostasis and activity ranging from apoptosis to proliferation. We recently described that the two compounds ceranib-2 (inhibiting acid ceramidase) and SKI-II [inhibiting the sphingosine kinases 1
Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent.
Zhang D
Journal of Cellular Biochemistry, 117(7), 1649-1657 (2016)
Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway.
Presneau N
British Journal of Cancer, 100(9), 1406-1414 (2009)

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