SAB4200764

Anti-Dystrophin Antibody

mouse monoclonal, MANDYS8

• Synonyme(s) : Anti-DMD
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• product name: Anti-Dystrophin antibody, Mouse monoclonal, clone MANDYS8, purified from hybridoma cell culture
• Source biologique: mouse
• Niveau de qualité: 200
• Forme d'anticorps: purified from hybridoma cell culture
• Type de produit anticorps: primary antibodies
• Clone: MANDYS8, monoclonal
• Forme: buffered aqueous solution
• Poids mol.: ~427 kDa
• Espèces réactives: porcine, rabbit, mouse, rat, human
• Validation améliorée: independent; Learn more about Antibody Enhanced Validation
• Concentration: ~1.0 mg/mL
• Technique(s): immunoblotting: suitable; immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections
• Isotype: IgG2b
• Numéro d'accès UniProt: P11532
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... DMD(1756)

Description

Description générale

Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with fragment of recombinant human dystrophin. Dystrophin is a 427 kD protein which joins the actin cytoskeleton to laminin. It possesses multiple domains and is localized to the extracellular matrix. Dystrophin contains NH2-terminal domain for actin binding. The C-terminal domain interacts with dystrophin associated protein (DAP).

Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.

Spécificité

Anti-Dystrophin antibody, Mouse monoclonal specifically recognizes an epitope located on the rod domain of the human dystrophin molecule.

Immunogène

recombinant human dystrophin

Application

Anti-Dystrophin antibody, Mouse monoclonal has been used in immunoblotting and immunohistochemistry.

Actions biochimiques/physiologiques

Dystrophin is known to prevent muscle fibre injury due to contraction.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.

Autres remarques

This product is for R&D use only, not for drug, household, or other uses.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable