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Key Documents

S9549

Sigma-Aldrich

Superoxide dismutase–polyethylene glycol from bovine erythrocytes

lyophilized powder, ≥1,350 units/mg protein

Synonyme(s) :

PEG-SOD

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About This Item

Numéro MDL:
MFCD00678115
Code UNSPSC :
12352204
Nomenclature NACRES :
NA.54

Forme

lyophilized powder

Niveau de qualité

200
400

Activité spécifique

≥1,350 units/mg protein

Poids mol.

5000 Da

Composition

Protein, ≥20% biuret

Ampleur du marquage

≥10 mol PEG per mol protein

Température de stockage

−20°C

Description générale

Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.

Application

Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:
  • in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells
  • as supplement in T cell culture to investigate its effect on cytokine production
  • in the preincubation of the carotid artery sections prior to DHE treatment

Actions biochimiques/physiologiques

Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.

Conditionnement

Package size based on protein content

Autres remarques

Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.

Forme physique

Lyophilized powder containing PEG plus 5% citrate buffer salts

Notes préparatoires

Enzyme derived

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H334

Conseils de prudence

P261 - P284 - P501

Classification des risques

Resp. Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Simone R Potje et al.
Free radical biology & medicine, 112, 587-596 (2017-09-14)
[Ru(terpy)(bdq)NO]
Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction
Supinski GS and Callahan LA
American Journal of Respiratory and Critical Care Medicine, 173(11), 1240-1247 (2006)
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity.
Yi X, Yuan D, Farr SA, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 191, 34-46 (2014)
Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia
Dayal S, et al.
PLoS ONE, 12(4), e0175732-e0175732 (2017)
Lingli Li et al.
Kidney international, 92(3), 625-633 (2017-04-12)
Myogenic contractions protect kidneys from barotrauma but are impaired in chronic kidney disease (CKD). Since myogenic contractions are enhanced by superoxide but impaired by hydrogen peroxide, we tested the hypothesis that they are counterregulated by superoxide and H2O2 from NOX2/p47phox and/or
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