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S5545

Sigma-Aldrich

Anti-Serotonin antibody produced in rabbit

whole antiserum

Synonyme(s) :

Anti-Serotonin, Rabbit Anti-Serotonin, Serotonin Detection Antibody

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About This Item

Numéro MDL:
MFCD00162839
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

whole antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Contient

15 mM sodium azide

Espèces réactives

rat, human

Conditionnement

antibody small pack of 25 μL

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:8,000 using sections of normal human appendix or serotonin-containing carcinoid tumors
immunohistochemistry (frozen sections): 1:5,000 using perfusion-fixed (4% paraformaldehyde), frozen sections of rat brain.

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTR1A(3350)

Description générale

Serotonin/5-HT (5-hydroxytryptamine) is a neurotransmitters present in the brain. Anti-Serotonin specifically stains enterochromaffin cells in formalin-fixed, paraffin-embedded sections of normal human appendix and serotonin-containing carcinoid tumors. In the central nervous system (CNS), the antiserum reacts with serotonin-containing fibers in perfusion-fixed, free-floating sections of rat brain.

Spécificité

The antibody reacts with serotonin-containing fibers in paraformaldehyde perfusion-fixed, frozen sections of rat brain. The product specifically stains enterochromaffin cells in formalin-fixed, paraffin embedded sections of normal human appendix and serotonin-containing carcinoid tumors.

Immunogène

Serotonin creatinine sulfate complex conjugated with formaldehyde to BSA.

Application

Anti-Serotonin antibody has been used in immunocytochemistry.

Actions biochimiques/physiologiques

Serotonin/5-HT, the midbrain raphe system controls mood, emotion, cognition and motor functions, circadian and neuroendocrine rhythms, like food intake, sleep and reproductive activity. It participates in natural reward-related physiology and behaviour, from feeding to sexual activity.

Forme physique

Supplied as a liquid containing 15 mM sodium azide as preservative.

Stockage et stabilité

For continuous use, store at 2-8 °C for a maximum of one month. For extended storage freeze in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Roles for serotonin in neuroembryogenesis.
Bernard H, et al.
Serotonin, 477-506 (1981)
Characterization of efferent projections of chemosensitive neurons in the caudal parapyramidal area of the rat brain
Ribas-Salgueiro JL, et al.
Brain Research Bulletin, 66(3), 235-248 (2005)
Allelic Variation of Human Serotonin Transporter Gene Expression
Armin H, et al.
Journal of Neurochemistry, 66(6), 2621-2624 (1996)
Martin Fritsch et al.
Frontiers in zoology, 10(1), 35-35 (2013-06-20)
One of the most interesting riddles within crustaceans is the origin of Cladocera (water fleas). Cladocerans are morphologically diverse and in terms of size and body segmentation differ considerably from other branchiopod taxa (Anostraca, Notostraca, Laevicaudata, Spinicaudata and Cyclestherida). In
Norio Miyamoto et al.
PloS one, 8(1), e55151-e55151 (2013-02-02)
Vestimentiferan tubeworms are marine invertebrates that inhabit chemosynthetic environments, and although recent molecular phylogenetic analyses have suggested that vestimentiferan tubeworms are derived from polychaete annelids, they show some morphological features that are different from other polychaetes. For example, vestimentiferans lack
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