S4572

SANT-1

≥98% (HPLC), powder, SHH antagonist

• Synonyme(s) : (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
• Formule empirique (notation de Hill): C₂₃H₂₇N₅
• Numéro CAS: 304909-07-7
• Poids moléculaire : 373.49
• Numéro MDL: MFCD01827306
• Code UNSPSC : 51111800
• ID de substance PubChem : 329824548
• Nomenclature NACRES : NA.77

Propriétés

• product name: SANT-1, ≥98% (HPLC), powder
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: −20°C
• Chaîne SMILES: Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4
• InChI: 1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
• Clé InChI: FOORCIAZMIWALX-JJIBRWJFSA-N

Description

Application

• SANT-1 has been used: to treat cells and study the effect of SANT1-mediated inhibition on hedgehog signaling
• in the generation of functional human pancreatic β cells in vitro
• to treat of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells² and chronic lymphocytic leukemia cells³ with SANT-1 induced cell death

Actions biochimiques/physiologiques

SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.

SANT-1 is known to induce apoptosis via Ras/NF-κB pathway in glioblastoma cells.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)