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Principaux documents

RAB0017

Sigma-Aldrich

Human ANGPTL4 ELISA Kit

for serum, plasma and cell culture supernatants

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About This Item

Code UNSPSC :
41116158
Nomenclature NACRES :
NA.32
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Espèces réactives

human

Conditionnement

kit of 96 wells (12 strips x 8 wells)

Technique(s)

ELISA: suitable
capture ELISA: suitable

Entrée

sample type cell culture supernatant(s)
sample type serum
sample type plasma

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 20 pg/mL
standard curve range: 27.4-20000 pg/mL

Méthode de détection

colorimetric

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... ANGPTL4(51378)

Description générale

The Human ANGPTL4 (Angiopoietin-like 4) ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human ANGPTL4 in serum, plasma and cell culture supernatants.

Immunogène

Recombinant Human Angiopoietin-like 4

Application

For research use only. Not for use in diagnostic procedures.
Human angiopoietin-like protein 4 (ANGPTL4) ELISA kit has been used for the quantitative measurement of ANGPTL4 in serum[1] and urinary samples.[2]

Actions biochimiques/physiologiques

Angiopoietin like 4 (ANGPTL4) possesses a characteristic large fibrinogen/angiopoietin like domain.[3] It inhibits lipoprotein lipase and thus increases plasma triglyceride levels.[4][5] The protein regulates the uptake of free fatty acids in fasting and fed conditions.[4] ANGPTL4 is also involved in homeostasis, insulin sensitivity and apoptosis of vascular endothelial cells. It has been reported to have a role in atherosclerosis and may modulate inflammatory responses.[6][3]

Autres remarques

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Composants de kit également disponibles séparément

Réf. du produit
Description
FDS
  • RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)FDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)FDS
  • RABSTOP3ELISA Stop Solution (Item I)FDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)FDS
  • RABWASH420X Wash Buffer (Item B)FDS

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Warning

Mentions de danger

H290

Conseils de prudence

P234 - P390

Classification des risques

Met. Corr. 1

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

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Certificats d'analyse (COA)

Lot/Batch Number
0602D0231
0601D0231
0228J0231
0325I0231
1222H0231

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Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Serum angiopoietin-like 4 is over-expressed in COPD patients: association with pulmonary function and inflammation.
Wu YQ
European Review for Medical and Pharmacological Sciences (2016)
Viktoria Gusarova et al.
Nature communications, 9(1), 2252-2252 (2018-06-15)
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and decrease risk of type 2 diabetes (T2D). We
Gabriel Cara-Fuentes et al.
PloS one, 12(4), e0176198-e0176198 (2017-04-26)
Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4 as a biomarker
Xun Chi et al.
The Journal of biological chemistry, 290(19), 11865-11877 (2015-03-27)
The release of fatty acids from plasma triglycerides for tissue uptake is critically dependent on the enzyme lipoprotein lipase (LPL). Hydrolysis of plasma triglycerides by LPL can be disrupted by the protein angiopoietin-like 4 (ANGPTL4), and ANGPTL4 has been shown
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels and predicts cardiovascular disease risk in Type 2 diabetic Tunisian population.
Abid K
Lipids in Health and Disease (2016)
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