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R5278

Sigma-Aldrich

Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit

affinity isolated antibody

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About This Item

Numéro MDL:
MFCD03097203
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, rat

Technique(s)

immunohistochemistry: 1-2 μg/mL using transgenic mouse retina
western blot: 1 μg/mL using using mouse lung extract

Numéro d'accès UniProt

Q63495

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... AGER(177)
mouse ... Ager(11596)
rat ... Ager(81722)

Description générale

Receptor for advanced glycation end products (RAGE), also known as advanced glycosylation end-product specific receptor (AGER) is encoded by the gene mapped to human chromosome 6p21. The encoded protein is a member of the immunoglobulin superfamily of cell surface molecules.

Immunogène

synthetic peptide corresponding to amino acid residues 362-380 from rat RAGE. This sequence is 100% conserved in mouse and 70% conserved in human.

Application

Anti-RAGE (Receptor for Advanced Glycation Endproducts) antibody produced in rabbit has been used in western blot and flow cytometry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Actions biochimiques/physiologiques

The soluble form of receptor for advanced glycation end products (RAGE) has a function in the Wnt pathway. RAGE has a role in the development of inflammatory and cellular damage, as well as cellular toxicity. It has been associated with diabetic atherosclerosis. AGER/RAGE also modulates cell proliferation, differentiation and apoptosis.{93

Forme physique

Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Association of RAGE gene Gly82Ser polymorphism with coronary artery disease and ischemic stroke
Ma W Q, et al.
Medicine, 95(49) (2016)
Susmita Barman et al.
Chemico-biological interactions, 307, 37-50 (2019-04-23)
Zinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in
Is there a role for high mobility group box 1 and the receptor for advanced glycation end products in the genesis of long-term cognitive impairment in sepsis survivors?
Felipe Dal-Pizzol et al.
Molecular medicine (Cambridge, Mass.), 18, 1357-1358 (2012-11-02)
Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population
Fu J, et al.
BioMed Research International (2017)
Hyperglycemia induces oxidative damage in SW872 cells.
Boyer F, et al.
Archives of Medical Research, 1(2), 66-78 (2014)
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