R1402

Raloxifene hydrochloride

solid

• Synonyme(s) : Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
• Formule empirique (notation de Hill): C₂₈H₂₇NO₄S · HCl
• Numéro CAS: 82640-04-8
• Poids moléculaire : 510.04
• Numéro MDL: MFCD01938233
• Code UNSPSC : 51111800
• ID de substance PubChem : 24278673
• Nomenclature NACRES : NA.77

Propriétés

• Forme: solid
• Niveau de qualité: 100
• Couleur: light yellow
• Solubilité: DMSO: soluble 28 mg/mL; H₂O: insoluble
• Auteur: Eli Lilly
• Chaîne SMILES: Cl[H].Oc1ccc(cc1)-c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4
• InChI: 1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
• Clé InChI: BKXVVCILCIUCLG-UHFFFAOYSA-N
• Informations sur le gène: human ... ESR2(2100)

Description

Application

Raloxifene hydrochloride has been used:

• as a competitive inhibitors for estrogen receptor α in breast cancer cells
• as an anti-resorptive agents to test its effect on improving bone mineral density (BMD) in six-month-old female ovariectomized rats
• to test effect on viability of esophageal adenocarcinoma cells

Actions biochimiques/physiologiques

Raloxifene is benzothiophene compound and is used in treating postmenopausal osteoporosis It comparatively induces lesser risk in developing thromboembolic events and cataracts compared to tamoxifen. Raloxifene also interacts with estrogen receptors and plasma proteins.

Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H351,H361d
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Carc. 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)