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P9879

Sigma-Aldrich

Procaine hydrochloride

≥97% (HPLC), powder, Na⁺ channel blocker

Synonyme(s) :

Ester 2-diéthylaminoéthyl d’acide 4-aminobenzoïque, Ester diéthylaminoéthyl d’acide p-aminobenzoïque hydrochloride, Novocaïne hydrochloride

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About This Item

Formule linéaire :
H2NC6H4CO2CH2CH2N(C2H5)2·HCl
Numéro CAS:
51-05-8
Poids moléculaire :
272.77
Numéro Beilstein :
3917802
Numéro CE :
200-077-2
Numéro MDL:
MFCD00013000
Code UNSPSC :
12352200
ID de substance PubChem :
24278665
Nomenclature NACRES :
NA.77

product name

Procaine hydrochloride, ≥97%

Niveau de qualité

200

Pureté

≥97%

Forme

powder

Pf

155-156 °C (lit.)

Auteur

Celgene

Chaîne SMILES 

Cl.CCN(CC)CCOC(=O)c1ccc(N)cc1

InChI

1S/C13H20N2O2.ClH/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3;1H

Clé InChI

HCBIBCJNVBAKAB-UHFFFAOYSA-N

Informations sur le gène

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Application

Procaine hydrochloride has been used as a component of Krebs Henseleit buffer for incubating the left ventricular cardiac tissue in its resting length. It has also been used as an inducer in M9 media for induction assay.

Actions biochimiques/physiologiques

Procaine is a Na+ channel blocker, commonly used as an anesthetic agent and is considered safer than cocaine. It is also useful as a painkiller to treat pain, associated with joints and tendons.

Caractéristiques et avantages

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H317

Classification des risques

Acute Tox. 3 Oral - Skin Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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J Dudel et al.
Journal of neurophysiology, 81(5), 2386-2397 (1999-05-13)
of quantal end-plate currents of mouse muscle by physostigmine and procaine. Quantal endplate currents (qEPCs) were recorded from hemidiaphragms of mice by means of a macro-patch-clamp electrode. Excitation was blocked with tetrodotoxin, and quantal release was elicited by depolarizing pulses
Ophthalmic Anaesthesia, 5-5 (2002)
Equine Anesthesia E-Book: Monitoring and Emergency Therapy, 215-215 (2002)
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation
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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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