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719900

Sigma-Aldrich

Resomer® RG 504 H, Poly(D,L-lactide-co-glycolide)

acid terminated, lactide:glycolide 50:50, Mw 38,000-54,000

Synonyme(s) :

PLGA

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About This Item

Formule linéaire :
[C3H4O2]x[C2H2O2]y
Numéro CAS:
26780-50-7
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Niveau de qualité

200

Forme

amorphous

Ratio alimentaire

lactide:glycolide 50:50

Poids mol.

Mw 38,000-54,000

Intervalle de dégradation

<3 months

Viscosité

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

Température de transition

Tg 46-50 °C

Température de stockage

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

Clé InChI

LCSKNASZPVZHEG-UHFFFAOYSA-N

Application

Resomer® RG 504 H, Poly(D, L-Lactide-co-Glycolide) can be used to fabricate a biodegradable hemostyptic device for safe and locally controlled release of thrombin which promotes local blood clot formation.

It can be used to preparepolymer nanospheres for encapsulating CuO, to form stimuli-responsivemultifunctional nanocarriers.

Informations légales

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
MKCV5944
BCCH5449
BCCG3293
BCCD7787
BCCC6288

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Hossein Kamali et al.
Materials science & engineering. C, Materials for biological applications, 96, 561-575 (2019-01-05)
An in situ forming gel (ISFG) of buprenorphine (BP) was prepared using PLGA-PEG-PLGA (triblock) and N‑methyl‑2‑pyrrolidone as solvent for decreasing the initial burst release. Supercritical CO2 method was used for ring opening polymerization of triblock. The optimum formulation of ISFG
Niranjan G Kotla et al.
Nanomaterials (Basel, Switzerland), 9(9) (2019-09-05)
There is a pressing clinical need for advanced colon-specific local drug delivery systems that can provide major advantages in treating diseases associated with the colon, such as inflammatory bowel disease (IBD) and colon cancer. A precise colon targeted drug delivery
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
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Articles

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Poly(Glycerol Sebacate) in Tissue Engineering

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

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