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P9159

Sigma-Aldrich

Piperidine-4-sulfonic acid

Synonyme(s) :

P4S

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About This Item

Formule empirique (notation de Hill):
C5H11NO3S
Numéro CAS:
72450-62-5
Poids moléculaire :
165.21
Numéro MDL:
MFCD00055097
Code UNSPSC :
12352106
ID de substance PubChem :
24278165
Nomenclature NACRES :
NA.77

Forme

powder

Chaîne SMILES 

OS(=O)(=O)C1CCNCC1

InChI

1S/C5H11NO3S/c7-10(8,9)5-1-3-6-4-2-5/h5-6H,1-4H2,(H,7,8,9)

Clé InChI

UGBJGGRINDTHIH-UHFFFAOYSA-N

Informations sur le gène

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)

Actions biochimiques/physiologiques

GABAA receptor agonist.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Angelo Keramidas et al.
The Journal of physiology, 575(Pt 1), 11-22 (2006-06-10)
The binding of the neurotransmitter GABA induces conformational changes in the GABAA receptor (GABAAR), leading to the opening of a gate that controls ion permeation through an integral transmembrane pore. A number of structural elements within each subunit, located near
S M O'Shea et al.
Brain research, 852(2), 344-348 (2000-03-11)
Using the whole-cell patch-clamp technique, we have determined that propofol, but not midazolam, increases the efficacy of piperidine-4-sulphonic acid (P4S), a partial agonist at alpha1beta1gamma2s, GABA(A) receptors expressed in HEK 293 cells. These findings are consistent with the idea that
E Galvez-Ruano et al.
Journal of neuroscience research, 42(5), 666-673 (1995-12-01)
Based on our molecular modeling investigations of the glycinergic receptor, we expanded our studies to similarly investigate the GABAergic receptor. New data suggest there may exist a slightly different agonistic mechanism for the molecules described herein as compared to glycine.
Marc C Gielen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(17), 5707-5715 (2012-04-28)
GABA(A) receptors (GABA(A)Rs) composed of αβγ subunits are allosterically modulated by the benzodiazepines (BDZs). Agonists at the BDZ binding site potentiate submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA. Although BDZs were initially thought to affect
Ko Ko et al.
Journal of medical virology (2020-06-25)
This study aimed to investigate the prevalence trend of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and their genotype distribution among hemodialysis patients, determining their long-term prognosis and the risk factors to the mortality. This cohort study
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