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M3949

Sigma-Aldrich

MST-312

≥98% (HPLC)

Synonyme(s) :

N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]

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About This Item

Formule empirique (notation de Hill):
C20H16N2O6
Numéro CAS:
368449-04-1
Poids moléculaire :
380.35
Numéro MDL:
MFCD24368986
Code UNSPSC :
12352200
ID de substance PubChem :
329817985
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Couleur

off-white to light tan

Solubilité

DMSO: ≥20 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O

InChI

1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)

Clé InChI

MIQUEZGHEJGPJB-UHFFFAOYSA-N

Application

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Actions biochimiques/physiologiques

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Laurent Lacroix et al.
Nucleic acids research, 39(4), e21-e21 (2010-11-26)
RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5'-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a
Salinomycin abolished STAT3 and STAT1 interactions and reduced telomerase activity in colorectal cancer cells.
Chung SS, et al.
Anticancer Research, 37(2), 445-453 (2017)
Combination treatment with flavonoid morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Chung SS, et al.
International Journal of Oncology, 49(2), 487-498 (2016)
Ponmathi Panneerpandian et al.
Antiviral research, 174, 104695-104695 (2019-12-18)
Yin Yang 1 (YY1) is a ubiquitous transcription factor with both transcriptional activating and repressing functions. Targeting YY1 is considered as a potential therapeutic strategy for several malignancies. Telomerase Reverse Transcriptase (TERT) is also considered as a potential target for
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The Analyst, 144(15), 4694-4701 (2019-07-04)
The development of facile and sensitive miRNA quantitative detection methods is a central challenge for the early diagnosis of miRNA-related diseases. Herein, we propose a strategy for a liposome-encoded magnetic bead-based DNA toehold-mediated DNA circuit for the simple and sensitive
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