M1559

Moxonidine hydrochloride

≥98%

• Synonyme(s) : 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride, BDF-5895
• Formule empirique (notation de Hill): C₉H₁₂ClN₅O · HCl
• Numéro CAS: 75438-58-3
• Poids moléculaire : 278.14
• Numéro MDL: MFCD06795643
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278537
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98%
• Auteur: Solvay
• Chaîne SMILES: Cl.COc1nc(C)nc(Cl)c1NC2=NCCN2
• InChI: 1S/C9H12ClN5O.ClH/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9;/h3-4H2,1-2H3,(H2,11,12,15);1H
• Clé InChI: ZZPAWQYZQVUVHX-UHFFFAOYSA-N
• Informations sur le gène: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , NISCH(11188)

Description

Application

Moxonidine hydrochloride has been used:

• as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method
• as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC)
• as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN)

Actions biochimiques/physiologiques

Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α_2C-adrenoceptor component.

Caractéristiques et avantages

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Solvay. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)