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I6658

Sigma-Aldrich

Isradipine

≥98% (HPLC), solid

Synonyme(s) :

4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester

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About This Item

Formule empirique (notation de Hill):
C19H21N3O5
Numéro CAS:
75695-93-1
Poids moléculaire :
371.39
Numéro MDL:
MFCD00153820
Code UNSPSC :
12352200
ID de substance PubChem :
24724517
Nomenclature NACRES :
NA.77

Description

Store under nitrogen

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Couleur

yellow

Solubilité

DMSO: >10 mg/mL

Auteur

Novartis

Température de stockage

2-8°C

Chaîne SMILES 

COC(=O)C1=C(C)NC(C)=C(C1c2cccc3nonc23)C(=O)OC(C)C

InChI

1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3

Clé InChI

HMJIYCCIJYRONP-UHFFFAOYSA-N

Informations sur le gène

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNA2D1(781)

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Application

Isradipine has been used to explore neuroprotective activity.

Actions biochimiques/physiologiques

Isradipine is considered as an active calcium channel blocker, used to treat hypertension.
L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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E Ilijic et al.
Neurobiology of disease, 43(2), 364-371 (2011-04-26)
The motor symptoms of Parkinson's disease (PD) are due to the progressive loss of dopamine (DA) neurons in substantia nigra pars compacta (SNc). Nothing is known to slow the progression of the disease, making the identification of potential neuroprotective agents
Fernando A Aguiar et al.
Electrophoresis, 32(19), 2673-2682 (2011-10-11)
A simple enantioselective method based on CE using CD as chiral selector was developed and validated for the determination of isradipine (IRD) enantiomers in a pharmaceutical formulation and for the determination of IRD enantiomers in degradation studies. After optimization, the
Thimmappa S Anekonda et al.
Neurobiology of disease, 41(1), 62-70 (2010-09-08)
There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and death. Here we investigated the feasibility
Dalton James Surmeier et al.
Antioxidants & redox signaling, 14(7), 1289-1301 (2010-08-18)
Parkinson's disease (PD) is a major world-wide health problem afflicting millions of the aged population. Factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and environmental toxins, have dominated public discussions of disease etiology. Although
Rodrigo Almeida Simões et al.
Analytical and bioanalytical chemistry, 399(7), 2435-2443 (2011-01-20)
An enantioselective liquid chromatographic method using two-phase hollow fiber liquid-phase microextraction (HF-LPME-HPLC) was developed for the determination of isradipine (ISR) enantiomers and its main metabolite (pyridine derivative of isradipine, PDI) in microsomal fractions isolated from rat liver. The analytes were
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