C9915

ω-Conotoxin GVIA

≥97% (HPLC)

• Formule empirique (notation de Hill): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• Numéro CAS: 106375-28-4
• Poids moléculaire : 3037.35
• Numéro MDL: MFCD00076620
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 200
• Pureté: ≥97% (HPLC)
• Forme: powder
• Composition: Peptide content, ~70%
• Température de stockage: −20°C
• Informations sur le gène: human ... CACNA1B(774) ; mouse ... CACNA1B(12287) ; rat ... CACNA1B(257648)

Description

Amino Acid Sequence

Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 [Disulfide Bridges: 1-16, 8-19, 15-26]

Application

ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.

Powerful probe for exploring the vertebrate pre-synaptic terminal.

Actions biochimiques/physiologiques

ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.

Blocks specific voltage-dependent N-type Ca²⁺ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)