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I5278

Sigma-Aldrich

Insulin-Like Growth Factor Binding Protein-3 human

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

Synonyme(s) :

IGF Binding Protein-3, IGFBP-3

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About This Item

Numéro MDL:
MFCD00285941
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in NSO cells

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Puissance

0.01-0.25 μg/mL

Poids mol.

29 kDa

Conditionnement

pkg of 25 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Numéro d'accès UniProt

P17936

Température de stockage

−20°C

Informations sur le gène

human ... IGFBP3(3486)

Actions biochimiques/physiologiques

Human IGFBP-3 is the major insulin-like growth factor (IGF) binding protein in plasma, where it exists in a ternary complex with IGF-I or IGF-II and the acid-labile subunit (ALS).
IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time. IGFBP3 binds to IGF-1. It is a tumor suppressor and is downregulated in many cancers. In serum, IGFs, IGFBP3 and the acid labile subunit (ALS) exist together as a complex. This complex is important for increasing the half life of serum IGFs.

Forme physique

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Remarque sur l'analyse

The biological acitivity is measured as the ability to inhibit the biological activity of 14 ng/ml recombinant human IGF-I on MCF-7 cells.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H312 + H332,H319

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Chuan-Wei Yang et al.
Journal of the American Medical Directors Association, 16(5), 365-370 (2014-12-31)
Previous studies have demonstrated the polymorphisms of insulinlike growth factor-1 (IGF-1) and its binding protein-3 (IGFBP3) genes could affect the circulating IGF-1 level. Moreover, the serum IGF-1 level was correlated with muscle size. This study aimed to explore the effect
Min Sun Kim et al.
Molecular and cellular biochemistry, 403(1-2), 107-113 (2015-02-11)
Nuclear factor-kappaB (NF-κB) is a transcription factor that is activated in various neoplasms, including gastric cancer. Insulin-like growth factor binding protein-3 (IGFBP-3) is a potent tumor suppressor and is significantly suppressed in a variety of cancers. Although IGFBP-3 has been
Kelley, K.M., et al.
The International Journal of Biochemistry & Cell Biology, 28, 619-637 (1995)
Spagnoli, A. and Rosenfeld, R.G.
Curr. Op. Endocrinology and Diabetes, 4, 1-1 (1997)
M L Cubbage et al.
The Journal of biological chemistry, 265(21), 12642-12649 (1990-07-25)
Insulin-like growth factor binding protein-3 (IGFBP-3) can modulate the mitogenic and metabolic effects of the insulin-like growth factors (IGFs). IGFBP-3 protein levels are developmentally regulated and influenced by a number of hormonal stimuli both in vitro and in vivo. As
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