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H9538

Sigma-Aldrich

HNE-DMA

hexane solution, ≥85% (GC)

Synonyme(s) :

(E)-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA

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About This Item

Formule empirique (notation de Hill):
C11H22O3
Poids moléculaire :
202.29
Numéro MDL:
MFCD07370138
Code UNSPSC :
12352200
ID de substance PubChem :
24724506
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥85% (GC)

Forme

hexane solution

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

CCCCCC(O)\C=C\C(OC)OC

InChI

1S/C11H22O3/c1-4-5-6-7-10(12)8-9-11(13-2)14-3/h8-12H,4-7H2,1-3H3/b9-8+

Clé InChI

ATGIHMSJAARJTF-CMDGGOBGSA-N

Actions biochimiques/physiologiques

Stable form of HNE; toxic second messenger of free radicals.

Notes préparatoires

To prepare HNE from HNE-DMA: evaporate the hexane under a gentle stream of nitrogen at room temperature. Working at 4 °C, add 1 ml (5 mg size) or 0.4 ml (2 mg size) of 1 mM cold HCl and stir for 45 minutes, or alternatively, close the vial and shake for 30 minutes. Upon hydrolysis, the initially cloudy solution becomes almost clear. This solution now has a pH of ∼3, contains ∼5 mg (5 mg size) or ∼2 mg (2 mg size) of the aldehyde (HNE), and is stable for at least 24 hours if kept at 4 °C. 6.8 mg HNE-DMA in 1 mL of hexane solution, giving 5 mg of HNE after hydrolysis.It is recommended that the freshly prepared HNE solution be used immediately.

Mention d'avertissement

Danger

Classification des risques

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

Organes cibles

Central nervous system, Nervous system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

-14.8 °F - closed cup

Point d'éclair (°C)

-26 °C - closed cup

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Anticorps anti-adduits de Michael avec le HNE (réduits) serum, from rabbit

Sigma-Aldrich

ABN249

Anticorps anti-adduits de Michael avec le HNE (réduits)

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