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Key Documents

C7956

Sigma-Aldrich

Coenzyme Q1

≥95%

Synonyme(s) :

2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, Ubiquinone-1, Ubiquinone-5

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About This Item

Formule empirique (notation de Hill):
C14H18O4
Numéro CAS:
727-81-1
Poids moléculaire :
250.29
Numéro MDL:
MFCD00274412
Code UNSPSC :
12352204
ID de substance PubChem :
24892585
Nomenclature NACRES :
NA.51

Niveau de qualité

100

Pureté

≥95%

Forme

liquid

Température de stockage

−20°C

Chaîne SMILES 

COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O

InChI

1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3

Clé InChI

SOECUQMRSRVZQQ-UHFFFAOYSA-N

Description générale

Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.

Application

Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.

Actions biochimiques/physiologiques

Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.

Autres remarques

Analog of coenzyme Q10 (not naturally occurring)
2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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P G Elmberger et al.
Lipids, 24(11), 919-930 (1989-11-01)
An effective system for perfusing rat liver using complete tissue culture medium and washed calf erythrocytes as oxygen carriers was devised. Infusion of taurocholate and glucose proved necessary to maintain stable metabolic activity and bile secretion during a 6-hr period.
Kenichi Okamura et al.
Journal of pharmacological sciences, 141(1), 56-63 (2019-10-16)
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important for
Lee R Swem et al.
The Journal of biological chemistry, 281(10), 6768-6775 (2006-01-13)
Rhodobacter capsulatus regulates many metabolic processes in response to the level of environmental oxygen and the energy state of the cell. One of the key global redox regulators of the cell's metabolic physiology is the sensor kinase RegB that controls
Giancarlo A Biagini et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(21), 8298-8303 (2012-05-09)
There is an urgent need for new antimalarial drugs with novel mechanisms of action to deliver effective control and eradication programs. Parasite resistance to all existing antimalarial classes, including the artemisinins, has been reported during their clinical use. A failure
Chang Sun et al.
Nature, 557(7703), 123-126 (2018-04-27)
Alternative complex III (ACIII) is a key component of the respiratory and/or photosynthetic electron transport chains of many bacteria1-3. Like complex III (also known as the bc1 complex), ACIII catalyses the oxidation of membrane-bound quinol and the reduction of cytochrome
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