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C4892

Sigma-Aldrich

γ-Cyclodextrin

≥98%

Synonyme(s) :

gamma-Cyclodextrin, Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin

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About This Item

Formule empirique (notation de Hill):
C48H80O40
Numéro CAS:
17465-86-0
Poids moléculaire :
1297.12
Numéro Beilstein :
78740
Numéro CE :
241-482-4
Numéro MDL:
MFCD00009595
Code UNSPSC :
12352005
ID de substance PubChem :
24892736
Nomenclature NACRES :
NA.22

Source biologique

microbial

Niveau de qualité

200

Pureté

≥98%

Forme

powder

Technique(s)

HPLC: suitable

Solubilité

1 M NH4OH: 50 mg/mL

Chaîne SMILES 

[H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O

InChI

1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1

Clé InChI

GDSRMADSINPKSL-HSEONFRVSA-N

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Description générale

γ-Cyclodextrin is a cyclic oligosaccharide containing eight glucose units linked by α-1,4-glycosidic bonds. It can form host-guest or inclusion complexes in aqueous solutions with various organic molecules. As a result, cyclodextrins are widely used in the food and pharmaceutical industries for the microencapsulation of sensitive fine chemicals.

Application

γ-Cyclodextrin can be used as:
  • A catalyst to synthesize substituted isoxazolidines via 1,3-dipolar cycloaddition of nitrones with styrenes and cinnamates.
  • An organic ligand to synthesize cyclodextrin-based metal-organic frameworks using biocompatible metal ions.
  • A reactant to synthesize O-perallylated cyclodextrins via perallylation with allyl halides in the presence of NaH.

Caractéristiques et avantages

  • Green and environment-friendly
  • No biological toxicity
  • Biodegradable

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Phatsawee Jansook et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 13(3), 336-350 (2010-11-26)
Study the complexation of dexamethasone in combinations of γ-cyclodextrin (γCD) and 2-hydroxypropyl-γ-cyclodextrin (HPγCD) with emphasis on solid characterization and development of aqueous dexamethasone eye drop suspension for drug delivery through sclera. Dexamethasone/cyclodextrin (dexamethasone/CD) solid complex systems were prepared and characterized
Sekar Karuppannan et al.
Chemistry, an Asian journal, 6(4), 964-984 (2011-01-29)
The past ten years have seen a spectacular development of chemical sensors based on the monomer-excimer dual luminescence of aromatic systems, such as pyrene. Either in the form of integrated or multicomponent molecular devices these chemosensors have been attracting a
S A A Almeida et al.
Talanta, 85(3), 1508-1516 (2011-08-03)
Solid-contact sensors for the selective screening of sulfadiazine (SDZ) in aquaculture waters are reported. Sensor surfaces were made from PVC membranes doped with tetraphenylporphyrin-manganese(III) chloride, α-cyclodextrin, β-cyclodextrin, or γ-cyclodextrin ionophores that were dispersed in plasticizer. Some membranes also presented a
B-G Kim et al.
British journal of pharmacology, 164(6), 1698-1710 (2011-05-19)
Although 3α-hydroxy, 5α-reduced pregnane steroids, such as allopregnanolone (AlloP) and tetrahydrodeoxycorticosterone, are endogenous positive modulators of postsynaptic GABA(A) receptors, the functional roles of endogenous neurosteroids in synaptic transmission are still largely unknown. In this study, the effect of AlloP on
Lei Wang et al.
Food chemistry, 141(3), 3072-3076 (2013-07-23)
In this study, we examined the production of γ-cyclodextrin (γ-CD) using γ-cyclodextrin glycosyltransferase (γ-CGTase) from Bacillus clarkii 7364. We investigated a variety of factors that affect the yield of γ-CD, including key factors such as solvent, substrate, temperature, pH, enzyme
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