390704

(2-Hydroxypropyl)-γ-cyclodextrin

extent of labeling: 0.6 molar substitution

• Synonyme(s) : HP-γ-CD, HPGCD, HGC
• Numéro CAS: 128446-34-4
• Code UNSPSC : 12352201
• Nomenclature NACRES : NA.22

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Activité optique: [α]20/D +145°, c = 1 in H₂O
• Poids mol.: average M_w ~1,580
• Ampleur du marquage: 0.6 molar substitution
• InChI: 1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1
• Clé InChI: ODLHGICHYURWBS-RYJYQAAZSA-N

Description

Description générale

(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.

Application

(2-Hydroxypropyl)-γ-cyclodextrin may be used:

• As a mobile phase additive in the study of the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase-high performance liquid chromatography (RP-HPLC) technique.
• As a chiral surfactant for the analysis of econazole by micellar electrokinetic chromatography (MEKC).
• As an analytical standard for the determination of the analyte in biological samples by HPLC.
• As a chiral selector for the identification of propiconazole by MEKC.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)