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B5057

Sigma-Aldrich

7-Benzyloxy-4-trifluoromethylcoumarin

≥99% (HPLC), solid

Synonyme(s) :

7-BFC

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About This Item

Formule empirique (notation de Hill):
C17H11F3O3
Poids moléculaire :
320.26
Numéro MDL:
MFCD01564466
Code UNSPSC :
12161501
ID de substance PubChem :
24891807
Nomenclature NACRES :
NA.47

product name

7-Benzyloxy-4-trifluoromethylcoumarin, ≥99% (HPLC), solid

Niveau de qualité

100

Pureté

≥99% (HPLC)

Forme

solid

Température de stockage

−20°C

Chaîne SMILES 

FC(F)(F)C1=CC(=O)Oc2cc(OCc3ccccc3)ccc12

InChI

1S/C17H11F3O3/c18-17(19,20)14-9-16(21)23-15-8-12(6-7-13(14)15)22-10-11-4-2-1-3-5-11/h1-9H,10H2

Clé InChI

WVKLERKKJXUPIK-UHFFFAOYSA-N

Informations sur le gène

rat ... Maoa(29253) , Maob(25750)

Application

7-Benzyloxy-4-trifluoromethylcoumarin has been used:

  • in the SBAD2-3x-AAGLY hepatocyte-like cell (HLC) functional assay to measure the cytochrome P450 3A4 (CYP3A4)-dependent activity
  • in O-dealkylation reaction to determine the activity of CYP3A
  • to measure the activity of CYP3A-mediated 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase activity (BFCOD)

Actions biochimiques/physiologiques

Metabolized primarily by cytochrome P450 isozymes CYP1A2 and CYP3A4.

Informations légales

Supplied by Gentest Corp., U.S. Patent Nos. 6,207,404.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302 + H312 + H332

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Jiannan Ding et al.
Chemosphere, 148, 21-31 (2016-01-23)
The aim of this study was to evaluate the interactive effects of fluoxetine (FLU), roxithromycin (ROX) and propranolol (PRP) on the bioaccumulation and biochemical responses in the crucian carp Carassius auratus. After 7 days of binary exposure (ROX + FLU
Elias M Oziolor et al.
Ecotoxicology (London, England), 26(6), 809-819 (2017-06-08)
There is increasing interest in quantifying the exposure and effects of anthropogenic contaminants in fish. Determination of exposures in wild fish is routinely performed, but methods to investigate potential effects are less established. One of the most relevant approaches would
Vamshi K Manda et al.
Phytotherapy research : PTR, 31(12), 1935-1945 (2017-10-27)
Kratom (Mitragyna speciosa), a native herb of Southeast Asia, is widely known for its psychoactive properties. Recent increase in the use of kratom as a recreational drug has increased the risk of its interaction with conventional drugs if taken concomitantly.
Manami Nishiwaki et al.
Scientific reports, 10(1), 17503-17503 (2020-10-17)
Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from
Viktoriia Burkina et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-14)
Water from wastewater treatment plants contains concentrations of pharmaceutically active compounds as high as micrograms per liter, which can adversely affect fish health and behavior, and contaminate the food chain. Here, we tested the ability of the common carp hepatic
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