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B169

Sigma-Aldrich

BRL 37344 sodium salt hydrate

solid

Synonyme(s) :

(±)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate, BRL 37344A

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About This Item

Formule empirique (notation de Hill):
C19H21ClNNaO4 · xH2O
Numéro CAS:
127299-93-8
Poids moléculaire :
385.82 (anhydrous basis)
Code UNSPSC :
12352200
ID de substance PubChem :
24277764
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Niveau de qualité

100

Forme

solid

Couleur

white

Solubilité

DMSO: 18 mg/mL, clear (warmed)

Chaîne SMILES 

O.[Na+].C[C@H](Cc1ccc(OCC([O-])=O)cc1)NC[C@H](O)c2cccc(Cl)c2

InChI

1S/C19H22ClNO4.Na.H2O/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);;1H2/q;+1;/p-1/t13-,18+;;/m1../s1

Clé InChI

YTPAKDODIXRQTF-BNTHFPBMSA-M

Informations sur le gène

human ... ADRB3(155)

Actions biochimiques/physiologiques

BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.

Caractéristiques et avantages

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Hygroscopic; store desiccated.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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S Tsujii et al.
Physiology & behavior, 63(4), 723-728 (1998-04-02)
This study evaluated the effect of peripheral injections of a beta3 adrenergic agonist, BRL-37,344 on food intake and whether this inhibition could be blocked by a nonspecific beta-adrenergic antagonist, propranolol, given peripherally or into the central nervous system. When BRL-37,344
M A Oriowo et al.
The Journal of pharmacology and experimental therapeutics, 277(1), 22-27 (1996-04-01)
The stimulation by BRL 37344 of lipolysis in rat adipose tissues, and of relaxation of the rat distal colon, is mediated by the beta-3 adrenoceptor. The stereochemical requirements of the beta-3 adrenoceptor are poorly understood. The activities of the four
K Koike et al.
European journal of pharmacology, 334(2-3), 217-221 (1997-11-22)
Beta-adrenoceptor-mediated relaxation of guinea pig taenia caecum was investigated by studying the effects of the beta3-adrenoceptor agonists, BRL37344A [(R*,R*)-(+/-)-4-[2'-[2-hydroxy-2-(3-chlorophenyl) ethylamino] propyl] phenoxyacetic acid sodium salt sesquihydrate] and BRL35135A [(R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl) ethylamine] propyl] phenoxyacetate hydrobromide]. BRL37344A and BRL35135A caused dose-dependent relaxation of
Ziwen Wang et al.
Molecular medicine (Cambridge, Mass.), 26(1), 54-54 (2020-06-07)
Our objective was to investigate the efficacy of the beta-3 adrenergic receptor (β3-AR) agonist BRL37344 for the prevention of liver steatosis and inflammation associated with nonalcoholic fatty liver disease (NAFLD). Four groups were established: a control group (given a standard
Junyu Lai et al.
Journal of cellular biochemistry, 120(10), 17872-17886 (2019-06-05)
Partial bladder outlet obstruction (PBOO) promotes bladder detrusor hyperplasia, increases bladder pressure, and decreases bladder compliance. To extensively explore its underlying mechanism, our study aimed to investigate the effect of pathological hydrostatic pressure on human bladder smooth muscle cell (hBSMC)
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