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A9719

Sigma-Aldrich

Arachidonyl-2′-chloroethylamide hydrate

≥97% (HPLC), oil

Synonyme(s) :

ACEA

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About This Item

Formule empirique (notation de Hill):
C22H36ClNO · xH2O
Numéro CAS:
220556-69-4
Poids moléculaire :
365.98 (anhydrous basis)
Numéro MDL:
MFCD02683581
Code UNSPSC :
51111800
ID de substance PubChem :
24891489
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥97% (HPLC)

Forme

oil

Contrôle du médicament

regulated under CDSA - not available from Sigma-Aldrich Canada

Conditions de stockage

desiccated

Couleur

brown-red

Solubilité

DMSO: soluble
H2O: insoluble

Température de stockage

−20°C

Chaîne SMILES 

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCCl

InChI

1S/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-

Clé InChI

SCJNCDSAIRBRIA-DOFZRALJSA-N

Informations sur le gène

mouse ... Cnr1(12801) , Cnr2(12802)
rat ... Cnr1(25248)

Actions biochimiques/physiologiques

Potent and selective neuronal CB1 cannabinoid receptor agonist.

Caractéristiques et avantages

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Photosensitive; store under argon or nitrogen.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yahya I Asiri et al.
Anesthesia and analgesia, 127(2), 548-555 (2017-10-11)
Development of new analgesics is limited by shortcomings of existing preclinical screening assays such as wide variations in response, suitability for a narrow range of analgesics, and propensity to induce tissue damage. Our aim was to determine the feasibility of
Chris L Baker et al.
British journal of pharmacology, 142(8), 1361-1367 (2004-07-28)
The vasoactive effects of the synthetic cannabinoid (CB) arachidonyl-2-chloroethylamide (ACEA) was tested in the knee joints of urethane-anaesthetised rats. Experiments were also performed to determine whether these vasomotor responses could be blocked by the selective CB(1) receptor antagonists AM251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide)
C J Hillard et al.
The Journal of pharmacology and experimental therapeutics, 289(3), 1427-1433 (1999-05-21)
Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. We
Akiko Tsuchida et al.
Scientific reports, 8(1), 7017-7017 (2018-05-08)
GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of GalNAc-DSLc4 in malignant properties of RCCs, we identified B4GalNAc-T2 as a responsible gene for the synthesis of
Tamás Oláh et al.
The Journal of physiology, 594(24), 7381-7398 (2016-10-28)
Marijuana was found to cause muscle weakness, although the exact regulatory role of its receptors (CB1 cannabinoid receptor; CB1R) in the excitation-contraction coupling (ECC) of mammalian skeletal muscle remains unknown. We found that CB1R activation or its knockout did not
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