W102

(R)-(+)-WIN 55,212-2 mesylate salt

≥98% (HPLC), powder, CB2 agonist

• Synonyme(s) : WIN552122 mesylate
• Formule linéaire : C₂₇H₂₆N₂O₃ · CH₃SO₃H
• Numéro CAS: 131543-23-2
• Poids moléculaire : 522.61
• Numéro MDL: MFCD00153882
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278779
• Nomenclature NACRES : NA.77

Propriétés

• product name: (R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC)
• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Contrôle du médicament: regulated under CDSA - not available from Sigma-Aldrich Canada
• Couleur: white to beige
• Solubilité: 0.1 M HCl: 0.25 mg/mL; DMSO: 12 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL; 0.1 M NaOH: insoluble; H₂O: insoluble
• Chaîne SMILES: CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@@H](CN6CCOCC6)n1c45
• InChI: 1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1
• Clé InChI: FSGCSTPOPBJYSX-VEIFNGETSA-N
• Informations sur le gène: human ... CNR1(1268) , CNR2(1269)

Description

Description générale

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Application

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

Actions biochimiques/physiologiques

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

Caractéristiques et avantages

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

The solubility of this chemical in DMF has not been determined. However, various sources state this chemical can be solubilized in about 30 mg/ml of DMF.

Informations légales

Sold with the permission of Sterling-Winthrop, Inc.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)