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A3234

Sigma-Aldrich

Apolipoprotein E4 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE and HPLC), lyophilized powder

Synonyme(s) :

ApoE4

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About This Item

Numéro MDL:
MFCD00285515
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Produit recombinant

expressed in E. coli

Niveau de qualité

100

Pureté

≥90% (SDS-PAGE and HPLC)

Forme

lyophilized powder

Numéro d'accès UniProt

P02649

Température de stockage

−20°C

Informations sur le gène

human ... APOE(348)

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Description générale

Apolipoprotein E (ApoE) is present in the brain and is mainly produced by astrocytes. It is a 299 amino acid glycoprotein of 34kDa. It is present in all classes of lipoproteins except LDL (low-density lipoprotein). APOE gene has three alleles, such as APOE ε3, APOE ε4 and APOE ε2. It is located on human chromosome 19q13.

Actions biochimiques/physiologiques

ApoE4 (apolipoprotein E4) is associated with AD (Alzheimer′s disease).
Apolipoprotein E4 is a member of the apolipoprotein E family of plasma lipoproteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. ApoE4 regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, regulate the activity of enzymes involved in lipid metabolism and bind amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer′s disease. ApoE exists in three major isoforms: E2, E3, and E4, which differ from one another by a single amino-acid substitution. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Forme physique

Lyophillized from a 0.2 μm filtered solution in 20 mM sodium phosphate, pH 7.8.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models
Huang Y
Biochemical Society Transactions, 120(4), 702-736 (2011)
Twenty years of the Alzheimer?s disease amyloid hypothesis: a genetic perspective
Tanzi R E and Bertram L
Cell, 120(4), 545-555 (2005)
Traumatic Brain Injury
Neurobiology of Brain Disorders, 120(4), 219-235 (2015)
Lipids and disorders of lipoprotein metabolism
Clinical Biochemistry, 120(4), 702-736 (2014)
Fatemeh Nouri Emamzadeh et al.
Neuroscience letters, 618, 146-151 (2016-02-28)
Parkinson's disease is a progressive brain disorder due to the degeneration of dopaminergic neurons in the substantia nigra. The accumulation of aggregated forms of α-synuclein protein into Lewy bodies is one of the characteristic features of this disease although the
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