T1001
Thyroglobulin from bovine thyroid
powder, ≥90% (agarose gel electrophoresis)
Synonyme(s) :
Globulins thyro, Thyractin
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About This Item
Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.61
Produits recommandés
Source biologique
bovine thyroid
Niveau de qualité
Pureté
≥90% (agarose gel electrophoresis)
Forme
powder
Poids mol.
~670 kDa
Composition
Iodine, ≥0.20%
Dosage de l'azote
13.0-16.0% total
Cendres
≤4%
Solubilité
H2O: 20 mg/mL
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
cow ... TG(280706)
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Application
Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Actions biochimiques/physiologiques
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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