A0987

n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate

≥98% (HPLC)

• Synonyme(s) : Cytosporone A n-amyl ester, compound 10i
• Formule empirique (notation de Hill): C₂₂H₃₄O₅
• Numéro CAS: 1257228-26-4
• Poids moléculaire : 378.50
• Numéro MDL: MFCD18632550
• Code UNSPSC : 12352200
• ID de substance PubChem : 329770645
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: DMSO: >65 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCCCCCCC(=O)c1c(O)cc(O)cc1CC(=O)OCCCCC
• InChI: 1S/C22H34O5/c1-3-5-7-8-9-10-12-19(24)22-17(14-18(23)16-20(22)25)15-21(26)27-13-11-6-4-2/h14,16,23,25H,3-13,15H2,1-2H3
• Clé InChI: FCKDHZVFIMRCNM-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate is a Nur77 agonist. Nur77 is a steroid orphan receptor that plays a critical role in regulating proliferation, differentiation and apoptosis. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate, a cytosporone B analog, is a stronger activator of Nur77 than it parent compound. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate treatment causes Nur77 migration to mitochondria, which results in mitochondrial Cyt c release into the cytoplasm and mitochondrial AIF redistribution in both the cytoplasm and nucleus.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable