95200

Vitamin B_12a hydrochloride

≥96% (UV), ≥96% (HPLC)

• Synonyme(s) : Hydroxocobalamin hydrochloride
• Formule empirique (notation de Hill): C₆₂H₈₉CoN₁₃O₁₅P · HCl
• Numéro CAS: 59461-30-2
• Poids moléculaire : 1382.82
• Numéro CE : 261-772-4
• Numéro MDL: MFCD00167463
• Code UNSPSC : 12352205
• ID de substance PubChem : 57653658
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: fermentation/recombinant
• Niveau de qualité: 100
• Pureté: ≥96% (HPLC); ≥96% (UV)
• Forme: powder or crystals
• Perte: ≤12% loss on drying, 20 °C (HV)
• Couleur: red to dark red
• Solubilité: methanol: 10 mg/mL at 20 °C, clear, dark red
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N([Co+]O)C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78
• InChI: 1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;;/m1.../s1
• Clé InChI: KEHNCSYXYMMUCO-BXSGNKEGSA-K

Description

Application

Vitamin B12a hydrochloride has been used as an antidote for cyanide poisoning.

Actions biochimiques/physiologiques

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

Autres remarques

Review

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)