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74667

Sigma-Aldrich

Nourseothricin sulfate

≥85% (HPLC)

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About This Item

Numéro CAS:
96736-11-7
Numéro MDL:
MFCD00165013
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.85

Source biologique

Streptomyces noursei

Niveau de qualité

100

Pureté

≥85% (HPLC)

Forme

solid

Couleur

white to light brown

Solubilité

H2O: soluble 200 mg/mL

Adéquation

suitable for (selection agent for molecular genetic research work)

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
fungi
mycobacteria
mycoplasma
parasites
viruses
yeast

Mode d’action

protein synthesis | interferes

Température de stockage

2-8°C

Description générale

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Actions biochimiques/physiologiques

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Conditionnement

10mg, 100mg

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Adrian J Verster et al.
G3 (Bethesda, Md.), 7(10), 3337-3347 (2017-08-26)
Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What
Mojca Mattiazzi Usaj et al.
Molecular systems biology, 16(2), e9243-e9243 (2020-02-18)
Our ability to understand the genotype-to-phenotype relationship is hindered by the lack of detailed understanding of phenotypes at a single-cell level. To systematically assess cell-to-cell phenotypic variability, we combined automated yeast genetics, high-content screening and neural network-based image analysis of
Dorota Fennessy et al.
PloS one, 9(5), e97683-e97683 (2014-05-23)
Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci
Joan Castells-Ballester et al.
International journal of molecular sciences, 20(24) (2019-12-15)
O-mannosylation is implicated in protein quality control in Saccharomyces cerevisiae due to the attachment of mannose to serine and threonine residues of un- or misfolded proteins in the endoplasmic reticulum (ER). This process also designated as unfolded protein O-mannosylation (UPOM)
Chetan C Rawal et al.
Cell reports, 31(5), 107603-107603 (2020-05-07)
An important but still enigmatic function of DNA:RNA hybrids is their role in DNA double-strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the human helicase Senataxin, is recruited at an HO endonuclease-induced DSB and
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