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48760

Sigma-Aldrich

Gentamicin sulfate from Micromonospora purpurea

≥590 μg/mg of gentamicin

Synonyme(s) :

Gentamicin C1

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About This Item

Formule linéaire :
C19-21H39-43N5O7 · 2.5H2SO4
Numéro CAS:
1405-41-0
Numéro CE :
215-778-9
Numéro MDL:
MFCD00270181
Code UNSPSC :
51281651
eCl@ss :
42020823
ID de substance PubChem :
329757401
Nomenclature NACRES :
NA.76

Source biologique

Micromonospora purpurea

Niveau de qualité

200

Forme

powder

Activité optique

[α]/D 107.0 to 121.0°, c = 10% in H2O

Activité spécifique

≥590 μg/mg of gentamicin

Poids mol.

Mr 694-723

Perte

≤18.0% loss on drying

Couleur

white to off-white

pH

3.5-5.5 (4% in H2O)

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Mode d’action

protein synthesis | interferes

Température de stockage

2-8°C

Chaîne SMILES 

OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

Clé InChI

RDEIXVOBVLKYNT-HDZPSJEVSA-N

Description générale

Chemical structure: aminoglycoside

Application

Used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It inhibits the growth of a wide variety of grampositive and gram-negative microorganisms including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.

Actions biochimiques/physiologiques

Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.

Conditionnement

1g, 5g, 25g

Définition de l'unité

1 U corresponds to 1 μg of the USP gentamicin sulfate reference standard

Notes préparatoires

Freely soluble in water, practically insoluble in alcohol and ether.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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