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Merck
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Key Documents

07076

Sigma-Aldrich

Castor Oil, Hydrogenated,Ethoxylated

Synonyme(s) :

Cremophor® RH 40, Macrogolglycerol hydroxystearate, PEG-40 castor oil, Polyoxyl 40 hydrogenated castor oil, RH 40

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About This Item

Numéro CAS:
61788-85-0
Numéro MDL:
MFCD01771439
Code UNSPSC :
12161900
Nomenclature NACRES :
NA.25

Impuretés

≤0.2% sulfated ash (verfied on random samples only)
≤1 ppm ethylene oxide
≤10 ppm dioxan
≤10 ppm heavy metals (verfied on random samples only)
≤2 ppm arsenic (verfied on random samples only)
≤2.0% water
≤5000 ppm acetic acid
≤620 ppm diethylene glycol
≤620 ppm ethylene glycol

Niveau de qualité

100

Résidus de calcination

≤0.25% (verfied onrandom samples only)

Indice d'acide

≤0.8 mg KOH/g

Indice d'hydroxyle

60‑75 mg KOH/g

Indice d'iode

≤1.0 g I2/100 g

Indice de saponification

50‑60 mg KOH/g

Adéquation

suitable for acidity or alkalinity

Catégories apparentées

Application

Castor Oil, Hydrogenated,Ethoxylated is used to solubilize vitamins, water insoluble active substances and essential oils in water or mixtures of water and alcohol.

Autres remarques

Castor Oil, Hydrogenated, Ethoxylated is the brand name for a range of non-ionic polyethoxylated detergents. It was developed for use as solubilizers and emulsifiers.

Remarque sur l'analyse

congealing temperature 16-26°C

Informations légales

Cremophor is a registered trademark of BASF SE

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

467.6 °F

Point d'éclair (°C)

242 °C

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Christofori M R R Nastiti et al.
Pharmaceutics, 12(2) (2020-02-06)
Resveratrol (RSV) is a potent lipophilic antioxidant with a low aqueous solubility. Novel nanoformulations have been successfully developed and evaluated to increase the potential of resveratrol as a skin targeting antioxidant. Nanoformulations were prepared using a spontaneous emulsification method, and
Ravouru Nagaraju et al.
Current drug discovery technologies, 6(4), 299-305 (2009-12-23)
The core-in-cup matrix tablets of Metoprolol succinate were prepared by wet granulation technique. Of all the investigated formulations, the optimized formulation of MS-09 followed zero-order kinetics of drug release. Trail on MS-09 was formulated using 7.5% hydrogenated castor-oil (HCO) and
Enas A Mahmoud et al.
AAPS PharmSciTech, 10(1), 183-192 (2009-02-25)
The purpose of this study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form emphasizing the excipients' effect on the development of a new dosage form. Systems composed of HCO-40, Transcutol HP
Jong Soo Woo et al.
Archives of pharmacal research, 30(1), 82-89 (2007-03-03)
Silymarin has been used to treat hepatobiliary diseases. However, it has a low bioavailability after being administered orally on account of its low solubility in water. In order to improve the dissolution rate, silymarin was formulated in the form of
Hideki Ichikawa et al.
Current drug delivery, 4(2), 131-140 (2007-04-26)
The effects of the formulation and particle composition of gadolinium (Gd)-containing lipid nanoemulsion (Gd-nanoLE) on the biodistribution of Gd after its intravenous (IV) injection in D(1)-179 melanoma-bearing hamsters were evaluated for its application in cancer neutron-capture therapy. Gd-nanoLEs whose particles
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