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Y0001665

Progesterone

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Progesterone, 4-Pregnene-3,20-dione

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About This Item

Formule empirique (notation de Hill):
C21H30O2
Numéro CAS:
57-83-0
Poids moléculaire :
314.46
Numéro Beilstein :
1915950
Numéro MDL:
MFCD00003658
Code UNSPSC :
41116107
ID de substance PubChem :
329831528
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

progesterone

Fabricant/nom de marque

EDQM

Pf

128-132 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

Clé InChI

RJKFOVLPORLFTN-LEKSSAKUSA-N

Informations sur le gène

human ... PGR(5241)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Progesterone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Steroid hormone produced by the corpus luteum.
Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1142

Progesterone, Pharmaceutical Secondary Standard; Certified Reference Material

1568007

Progesterone, United States Pharmacopeia (USP) Reference Standard

P3300000

Progesterone, European Pharmacopoeia (EP) Reference Standard

Y0001666

Progesterone, European Pharmacopoeia (EP) Reference Standard

Y0001667

Progesterone for impurity H identification, European Pharmacopoeia (EP) Reference Standard

BP449

Progesterone, British Pharmacopoeia (BP) Reference Standard

PHR2280

Progesterone Impurity J, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2563

11-Ketoprogesterone, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8932

(20R)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8933

(17α)-Pregn-4-ene-3,20-dione, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8935

(20S)-20-Hydroxypregn-4-en-3-one, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8939

(20R)-3-Oxopregn-4-en-20-yl acetate, Pharmaceutical Secondary Standard; Certified Reference Material

PHR8943

(20S)-3-Oxopregn-4-en-20-yl acetate

PHR2905

Progesterone Related Compound H, pharmaceutical secondary standard, certified reference material

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H351,H360FD,H362

Classification des risques

Carc. 2 - Lact. - Repr. 1A

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

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Sigma-Aldrich

P8783

Progesterone

Gunter von Minckwitz et al.
The Lancet. Oncology, 15(7), 747-756 (2014-05-06)
Preclinical data suggest that triple-negative breast cancers are sensitive to interstrand crosslinking agents, and that synergy may exist for the combination of a taxane, trastuzumab, and a platinum salt for HER2-positive breast cancer. We therefore aimed to assess the efficacy
Brett E Skolnick et al.
The New England journal of medicine, 371(26), 2467-2476 (2014-12-11)
Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. We investigated the efficacy and safety of progesterone in a large, prospective, phase
David W Wright et al.
The New England journal of medicine, 371(26), 2457-2466 (2014-12-11)
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Progesterone has been shown to improve neurologic outcome in multiple experimental models and two early-phase trials involving patients with TBI. We conducted a double-blind, multicenter clinical trial
A R Harmer et al.
The Journal of physiology, 592(3), 523-535 (2013-12-04)
Calcium cycling is integral to muscle performance during the rapid muscle contraction and relaxation of high-intensity exercise. Ca(2+) handling is altered by diabetes mellitus, but has not previously been investigated in human skeletal muscle. We investigated effects of high-intensity exercise
Eszter Papp et al.
The Journal of infectious diseases, 211(1), 10-18 (2014-07-18)
Protease inhibitor (PI)-based combination antiretroviral therapy (cART) is administered during pregnancy to prevent perinatal human immunodeficiency virus (HIV) transmission. However, PI use has been associated with adverse birth outcomes, including preterm delivery and small-for-gestational-age (SGA) births. The mechanisms underlying these
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